期刊文献+

可溶性肿瘤坏死因子受体测定在急性淋巴性白血病诊治中的应用 被引量:1

The Application of Clinical Diagnosis and Treatment of Serum Soluble Receptors for Tumor Necrosis Factor in Acute Lymphocytic Leukemia
原文传递
导出
摘要 目的:探讨急性淋巴性白血病(ALL)患者血浆可溶性肿瘤坏死因子受体(sTNFR s)变化及其意义。方法:采用酶联免疫吸附法测定了15例ALL患者血浆sTNFR-Ⅰ和sTNFR-Ⅱ水平及血清肿瘤坏死因子α(TNFα),并以20例正常人作对照。结果:ALL患者血浆sTNFR-Ⅰ,sTNFR-Ⅱ和TNFα水平显著升高,与正常对照组差异有显著性(P<0.01)。结论:由sTN-FR-Ⅰ和sTNFR-Ⅱ介导的sTNFα的异常分泌可能是导致ALL细胞增殖的一个重要因素,该受体的测定可以判断患者的疾病状态,对治疗效果同样有评估作用。 Objective To investigate the changes and significance of serum soluble receptors for tumour necrosis factor in acute lymphocytic leukemia(ALL)patients.Methods Serum tumour necrosis factor receptor Ⅰ(sTNFR-Ⅰ),Serum tumour necrosis factor receptorⅡ(sTNFR-Ⅱ),and Serum tumour necrosis factor(TNFα) were detected with enzyme-link immunosorbent assay in 15 ALL and 20 health human being.Results sTNFR-Ⅰ,sTNFR-Ⅱand serum TNFa in ALL patients were significantly higher than normal control(P<0.01).Conclusion The serum T...
出处 《湖南师范大学学报(医学版)》 2008年第3期56-57,共2页 Journal of Hunan Normal University(Medical Sciences)
关键词 急性 淋巴细胞 白血病 受体 肿瘤坏死因子 acute lymphocytic leukemia recepors tumor necrosis factor
  • 相关文献

参考文献2

二级参考文献11

  • 1小儿急性白血病诊疗建议(修订草案)[J].中华儿科杂志,1993,31(5):285-287. 被引量:167
  • 2刘小菁.可溶性肿瘤坏死因子受体研究进展[J].国外医学(临床生物化学与检验学分册),1995,16(3):112-114. 被引量:7
  • 3蔡竟惠 周柱.102例造血系统肿瘤患者血清可溶性肿瘤坏死因子受体-Ⅰ测定[J].中华血液学杂志,2000,9(1):28-28.
  • 4Diez-Ruiz A, Tilz G P,Zangerla R, et al. Soluble receptors for tumor necrosisfactor in clinical laboratory diagnosis. Eur J Hematol,1995,54:1~8
  • 5Aderka D, Engelmann H, Maor Y, et al. Stabilization of the bioactivity of tumornecrosis factor receptors.J Exp Med,1992,175:323~329
  • 6Hohmann H P, Remy R, Brockhaus M, et al. Two different cell types have differentmajor receptors for human tumor necrosis factor (TNFa). J Biol Chem,1989,64:14 927~14934
  • 7Black P H. Shedding from normal and cancer cell surface. N Engl J Med,1980,303:1415~1416
  • 8Salles G, Bienvenu J, Bastion Y, et al. Elevated circulating levels of TNFa and itsP55 soluble receptor are associated with an adverse prognosis in lymphoma patients. Br JHaematol,1996,93:352~359
  • 9Gruss H J, Dolken G, Brach M A, et al. The significance of serum levels of soluble60kDa receptors for tumor necrosis factor in patients with Hodgkin'sdisease.Leukemia,1993,7:1339~1343
  • 10Digel W, Porzsolt F, Schmid M, et al. High levels of circulating soluble receptorsfor tumor necrosis factor in hairy cell leukemia and type B chronic lymphocytic leukemia.J Clin Invest, 1992,89:1690~1693 (收稿 1999-12-13)

同被引文献11

引证文献1

二级引证文献7

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部