不同体重雌性大鼠对维甲酸反应的研究

Study of the Reactions to Retinoic Acid in Different Weight Female Rats

目的:探讨维甲酸诱导雌性大鼠骨质疏松模型时,不同体重大鼠对维甲酸的反应。方法:193只10月龄不同体重(313.03±38.86)的雌性大鼠,按体重分为8组,分别灌服维甲酸2周,每3天测重1次,比较不同体重大鼠的体重变化以及停用维甲酸后体重的恢复。比较不同体重组大鼠在灌服维甲酸时死亡和患病情况。结果:在维甲酸诱导雌性大鼠骨质疏松模型时,大鼠体重均明显下降,高体重组(380.46±7.50)大鼠的体重下降最为明显。低体重组(237.43±7.98和260.53±6.27)大鼠的体重下降较少。但不同组大鼠的死亡率和患病率的组间与整体无统计学差异。结论:10月龄不同体重(313.03±38.86)的雌性大鼠,在维甲酸诱导骨质疏松模型时,体重与其死亡率和患病率无明显关系。

Objective To study the female rats with retinoic acid-induced osteoporosis model,the different weight of rats toretinoic acid response.Method 193 10-month-old different body weight(313.03 ± 38.86) of female rats were divided into 8 groups according to the weight fed with retinoic acid for 2 weeks,3 days each weigh 1 to compare the different weight of the body weight of rats Retinoic acid out,as well as changes in body weight after recovery.Comparing the prevalence and the mortality rate of different bodie w...