磷酸钙骨水泥生物材料用磷酸四钙的制备

Preparation of tetracalcium phosphate for calcium phosphate cements biomaterials

采用CaCO3和CaHPO4的混合粉分别在空气和真空2种气氛条件下制备磷酸四钙。结果表明:在空气中较难制得磷酸四钙,这主要是由于潮湿的空气中含有较多水分和制备工艺中采取随炉缓慢冷却,对反应产生了不利影响;在真空条件下,采用n(Ca)∶n(P)=2∶1,1.8∶1和1.5∶1的3种混合粉均容易制得磷酸四钙,但同时都含有其它杂质相,对其纯度有影响,其中以n(Ca)∶n(P)=2∶1的混合粉制备的磷酸四钙纯度最高,其产物中仅含少量CaO杂质相,这种磷酸四钙可用于磷酸钙骨水泥。

The tetracalcium phosphate were prepared using CaCO_3 and CaHPO_4 powders both in air and in vacuum. Results show that it is difficult to prepare tetracalcium phosphate in air because air is moisture-bearing medium and a process of slowly cooling in furnace has been used; however the tetracalcium phosphate can be prepared easy in vacuum with n(Ca)∶n(P)=2∶1, 1.8∶1 or 1.5∶1 in despite of existing impurity in some cases. And when n(Ca)∶n(P)=2∶1 is used the highest purity can be achieved with a small amount of impurity (CaO) left. Further tests prove that this kind of tetracalcium phosphate can be used for calcium phosphate cements as biomaterial.