摘要
By investigating the effect of the amount of water, the ratio of aldehyde and allyl- bromide, and the reaction temperature on the transformation, 2,4,6-trisubstituted tetrahydro- pyrans are synthesized by a novel tandem Barbier-Prins-cyclization reaction in the presence of micro-amount of water under mild conditions. The experiment is easy to perform without the need to exclude moisture or air. The reaction is atomic economical and environmentally benign.
By investigating the effect of the amount of water, the ratio of aldehyde and allyl- bromide, and the reaction temperature on the transformation, 2,4,6-trisubstituted tetrahydro- pyrans are synthesized by a novel tandem Barbier-Prins-cyclization reaction in the presence of micro-amount of water under mild conditions. The experiment is easy to perform without the need to exclude moisture or air. The reaction is atomic economical and environmentally benign.
基金
the Key Foundation of the Ministry of Education of China
National Natural Science Foundation of China(Grant No.20372033).
