Omega-3脂肪酸对颈动脉粥样硬化患者血管内皮功能影响的临床研究

Clinical Study on the effect of Omega - 3 fatty acids on Endothelial Functions in patients with carotid atherosclerosis

目的探讨Omega-3不饱和脂肪酸对颈动脉粥样硬化患者血管内皮功能的影响。方法将40例经颈动脉超声证实存在颈动脉粥样硬化的患者随机分为常规治疗组(原有疾病治疗)和Omega-3治疗组(常规治疗+Omega-3 2250mg每日三次服用)观察4周,治疗前后测定血清内皮素(ET),一氧化氮(NO) 及von Willebrand因子(vWF)的变化。结果常规治疗组:ET及NO及NO／ET指标组内治疗前后无明显差异(P>0．05),vWF指标较治疗前上升(P<0．05)。Omega -3治疗组:ET,NO及NO／ET,vWF指标组内治疗前后存在差异(P<0．05)。组间比较ET(P<0．01)NO(P=0．05),NO／ET(P<0．01)及VWF(P<0．05)治疗前后存在差异。结论 Omega-3不饱和脂肪酸对存在动脉粥样硬化患者的血管内皮功能有一定的改善作用。

Objective To evaluate the effects of Omega-3 fatty acids on endothelial function in patients with carotid atheresclerosis. Methods From September,2004, to January, 2005,40 patients with carotid athersclerosis were randomly assigned supplements of Omega- 3 fatty acids (2250mg daily and normal treatment, n=22), others taked normal treatment(n=18). Before study,plasma vWF, ET and NO were tested. After 4 weeks a-gain. Plasma levels of ET,NO,vWF were measured with radioimmunoassay,enzymatic assay or ELISA as indexes of endothelial function. Reults The plasma vWF and ET levels were significantly lowered, NO and NO/ET levels were higher in patients who were treated with Omega-3 fatty acids. Conclusion Compared with baseline values, the plasma vWF and ET levels were decreased, but NO and NO/ET levels were increased by treatment with Omega - 3 fatty acids in patients with carotid atheresclerosis.