灯盏细辛注射液加用纳洛酮治疗急性脑梗死

Treatment of Acute Cerebral Infarction by the Use of Herba Erigerontis Injection plus Naloxone

目的观察灯盏细辛注射液加用纳洛酮治疗急性脑梗死患者的临床疗效。方法80例急性脑梗死患者发病72 h 内的急性期病例随机分为治疗组和对照组两组,两组均予降颅压、控制血压、抗生素控制感染、维持水电解质酸碱平衡及对症支持治疗,对照组另用灯盏细辛注射液静脉滴注,治疗组用灯盏细辛注射液加用纳洛酮静脉滴注,均每日1次,连用2周。观察两组治疗前后的临床疗效、神经功能缺损评分。结果治疗组总有效率为92.5%,对照组为77.5%,两组疗效对比、神经功能缺损评分改善治疗组均明显优于对照组,有统计学意义(P<0.01)。均未发现有明显不良反应。结论灯盏细辛注射液和纳洛酮的联合使用可改善脑梗死神经功能缺损,提高疗效,降低致残率。

Objective To observe the clinical effect of herba erigerontis injection plus naloxone on treating acute cerebral infarction.Methods All 80 patients with acute cerebral infarction were randomly divided into two groups: the treatment group(40 cases)and the control group(40 cases).The treatment group was treated with herba erigeron- tis injection plus naloxone while the control group was treated with herba erigerontis injection once a day for 14 days. Two groups were given the same routine treatment,such as anti-infection,controlling blood pressure,correcting hydro-electrolytic disorder,lowering intracranial pressure,etc.Results The overall effective rate amounted to 92.5% in the treatment group and 77.5% in the control group.There was a significant difference,Improvement of dys- neuria scores in the treatment group was superior to that in the control group and there was a statistical significance (P<0.01).Conclusion Herba erigerontis injection plus naloxone is an effective and safe drug for treating acute cerebral infarction.It can improve degree of neurofunctional deficits and decrease the disabled rate.