精神分裂症血清S100B蛋白的研究

The clinical study on the serum concentration of S100B protein in schizophrenia

目的:探讨精神分裂症患者血清S100B蛋白水平的临床意义。方法:采用ELISA法检测40例精神分裂症患者血清S100B蛋白浓度,应用阴性与阳性症状量表评定精神分裂症患者组的精神症状;40例为正常对照组。结果:精神分裂症患者组血清S100B蛋白水平明显高于对照组。血清S100B蛋白水平与PANSS量表中的总分(r=0.356,P=0.041)和阴性症状分(r=0.415,P=0.010)成正相关。结论:精神分裂症患者PANSS量表中的总分和阴性症状分与S100B蛋白水平相关,也许S100B蛋白水平可作为精神分裂症诊断和判断病情严重程度的指标。

Objective:To investigate the clinical signification of the serum concentration of S100B protein in schizophrenia. Methods:The serum concentrations of S100B protein were detected in a sample of 40 schizophrenic patients and 40 healthy controls,using the enzyme linked immunosorbent assay (ELISA).The patients were examined with the positive and negative syndrome scale (PANSS) to assess their psychiatric symptoms.Results:the levels of serum concentration of S100B protein in schizophrenia group were significantly higher than those in healthy control group.The levels of serum S100B concentration were positively associated with PANSS total scores (r=0.356,P=0.041) and negative scores (r=0.415,P=0.010).Conclusions:The PANSS total scores and negative scores of schizophrenic patients were associated with the levels of serum S100B concentration.Perhaps the levels of serum S100B concentration could be regarded as an indicator helping to diagnose the schizophrenia and to assess the severity.