中医体质与慢性HBV感染者肝纤维化的相关性探讨

DISCUSSION ON CORRELATION BETWEEN CONSTITUTION OF TCM AND HEPATIC PATHOLOGICAL CHANGES IN HBV INFECTED PERSONS

目的:探讨中医体质与慢性HBV感染者肝纤维化的关系。方法:以王琦中医体质最新分类(去除特禀质)法为标准判断本院就诊的病理资料完整的131例慢性HBV感染者的体质类型,依据肝组织纤维化程度进行分组,比较各组间体质类型分布的差异。结果:慢性HBV感染者S0组平和质多见,S1～2组平和质、气虚质、阴虚质多见,S3～4组平和质、气虚质、阴虚质多见,S1～2组和S3～4组少数患者表现为痰湿质和瘀血质;组间体质类型的总体分布不同,差异有统计学意义(P<0.01);随着纤维化程度的增高,气虚质、阴虚质等病理体质类型出现频率明显增加。结论:气虚质和阴虚质慢性HBV感染者可能容易出现进展性肝纤维化。

Objective:To discuss the relationship between constitution of TCM and hepatic pathological changes in HBV infected person.Meothods:131 cases of HBV infected were classified according to Wangqi's classification method of TCM constitution, Groups were divided based on hepatocirrhosis severity, comparing the difference of constitution distribution in each group.Results: Normal constitution was the most common-seen at stage 0 of hepatic pathological changes; normal,deficiency of qi and deficiency of yin constitution types were the commom-seen at stage 1～2; normal, dificiency of qi and deficiencyof yin constitution types were the most common-seen at stage 3～4; small quantity patients at stage 1～2 and 3～4 showed phlegm-dampness and blood stasis constitution; the distribution of constitution was different in each group; the occurrence frequency of qi deficiency and yin deficiency was obviously decreased with hepatocirrhosis severity getting worse.Conclusion: HBV infected persons of qi deficiency and yin deficiency constitution were easy to appearing advanced hepatocirrhosis.