白介素2联合COP方案治疗NHL23例疗效分析

Therapeutic Andiyses of IL-2 Combined wwitn cop scneme in non -Hodgkin lympnoma:23cases repore

目的:观察白介素2联合环磷酰胺,长春新硷,泼尼松(COP)治疗非霍奇金林巴瘤(NHL)的临床疗效。方法:对照组26例患者予COP方案(环磷酰胺800 mg/d、d1,长春新硷1.5 mg/d、d1,泼尼松100 mg/d、d1～5),3周1个疗程、治疗6个疗程;治疗组(白介素2联合COP)23例患者,白介素2 100万IU/d、d1～15,1个疗程,环磷酰胺(CTX)800 mg/d、d1,长春新硷1.5 mg/d、d1,泼尼松100 mg/d、d1～5,3周1个疗程,治疗6个疗程。结果:对照组26例患者的总有效率69.22%(18例),CR率53.84%(14例);治疗组23例患者总有效率95.64%(22例),CR率69.56%(16例),两组对照有明显统计学意义(P<0.01)。结论:白介素2联合COP方案治疗NHL有效。

Objective: TO obsere IL - 2 Combining cyciophosphamidum vincristim prednisone (cop scheme) to cure NHL. Methods:26cases of comparison group are given cop scheme(cyciophosphamidum 800 mg/d, d1,vincristiml.5mg/d,d1 prednisone 100 mg po d1 - 5 ,3w ds one course, 6courses) ;23cases or group dre given cop scheme combined with IL - 2 , IL - 2 100ten thou sdndu /d d1-15; cyciophosphamidum (CTX) 800mg/d, d1 vincristim 1.5mg/d, d1 prednisone 100 mg po d1-5, das one course, 6courses.Results: The effective rate of 26cases in comparison group is 69.22% (18cases)The CR rate is 53.84% (14cases) ,The effective rdte of 23cases in group is 95.64% (21cases) , the CR rate is 69.56% (16cdses),there is obvious seatisnic medning between the two comparisons(P<0.01).Conclusions: conclusion:It is efflciene for IL - 2 to use cop scheme to cure NHL.