玫瑰糠疹患者血清中IL-2、IL-10和IFN-γ水平的研究

COMPARISON OF SERUM LEVELS OF IL-2,IL-10 AND IFN-γ IN PATIENTS WITH PITYRIASIS ROSEA

目的研究不同病程玫瑰糠疹(pityriasis rosea,PR)患者血清中白细胞介素2(interleukin-2,IL-2)、白细胞介素10(interleukin-10,IL-10)和干扰素Ⅱ型(interferon type Ⅱ,IFN-γ)的水平。方法采取双抗体夹心ELISA法检测PR患者病程≤4周时及病程>4周时血清中IL-2、IL-10和IFN-γ的水平。结果病程≤4周时PR患者血清中IL-2、IL-10的水平较对照组降低(P<0.01,P<0.05);病程>4周时IL-2水平仍低(P<0.01),IL-10恢复正常水平,IFN-γ水平较对照组无明显改变(P>0.05);但IFN-γ水平在病程>4周时低于病程≤4周时的水平(P<0.05)。结论 PR患者的Th1及Th2细胞亚群均受抑制,外周血Th1/Th2型细胞因子失调在PR的发生发展中可能起作用。

Objective To investigate the serum levels of cytokines interleukin-2 (IL-2), interleukin-10(IL-10) and interferon type Ⅱ(IFN-γ) in patients with different stages of pityriasis rosea(PR).Methods Levels of IL-2,IL-10 and IFN-γ were detected by using double antibody sandwich enzyme-linked immunosorbent assay in patients with different stage of PR (less than 4 weeks and more than 4 weeks).Results The serum IL-2 and IL-10 level was lower in PR patients within 4 weeks than that in the control group; The serum IL-2 level was still lower in PR patients more than 4 weeks and IL-10 level returned to normal; IFN-γ level had no significant changes. Conclusion Th1 and Th2 cell subsets were suppressed in PR patients.The deregulation of Th1/ Th2 cytokines in PR patients may play a role in the pathogenesis and progression of PR.