苁蓉益肾颗粒联合环孢菌素A治疗男性纯红细胞再生障碍的临床研究

CLINICAL STUDY ON MEN'S PURE RED CELL APLASIA TREATED WITH CONGRONG YISHEN GRANULE AND CICLOSPORIN A

目的:探讨苁蓉益肾颗粒联合环孢菌素A治疗男性纯红细胞再生障碍的疗效和机制。方法:48例患者随机分为两组,治疗组(24例)用苁蓉益肾颗粒联合环孢菌素A治疗,对照组(24例)用安特尔联合环孢菌素A治疗,两组均治疗12周,观察治疗前后两组相关临床指标(包括血红蛋白、红细胞、红细胞压积、睾酮、雌二醇、泌乳素、淋巴细胞亚群)的变化。结果:治疗12周后两组贫血指标均比治疗前有明显改善,两组疗效无明显差异。治疗后两组雌二醇、泌乳素水平较治疗前下降,睾酮水平较治疗前明显上升,两组对比无明显差异。淋巴细胞亚群分析表明治疗后两组CD3+、CD8+T淋巴细胞较治疗前明显下降,CD4+T淋巴细胞、CD4/CD8比值较治疗前明显上升(P<0.01),治疗后两组对比有统计学差异。结论:苁蓉益肾颗粒联合环孢菌素A治疗男性纯红细胞再生障碍有良好疗效,苁蓉益肾颗粒可通过促进睾酮分泌,刺激红细胞生成,并具有免疫调节作用。

Objective:To observe the effect and explore the mechanism of congrong yishen granule and ciclosporin A on men's pure red cell aplastic anemia.Methods: 48 cases with pure red cell aplastic anemia were randomly divided into two groups,the treatment group was given congrong yishen granule and ciclosporin A,the control group was given danazol and ciclosporin A,all patients were treated 12 weeks. Changes of clinical efficacy related indexes such as RBC,Hb,Hct,E2,PRL,T and T lymphocyte subgroup were observed.Resu...