顺铂不同给药方案配合同期放疗治疗局部晚期鼻咽癌65例

Different Administration Regimens of Cisplatin Combined with Concurrent Radiotherapy for 65 Cases with Locally Advanced Nasopharyngeal Carcinoma

[目的]比较顺铂单药每周方案与每3周方案配合同期放疗治疗局部晚期鼻咽癌的近期疗效、毒副作用及耐受性。[方法]65例局部晚期鼻咽癌患者,随机分为两组,治疗组:33例患者接受顺铂每周方案,30mg/m2,d1;对照组:32例患者接受顺铂单药每3周方案,80mg/m2,d1、d22、d43。两组均配合常规放射治疗,放疗方法相同。[结果]治疗组与对照组患者的近期有效率均为100%;治疗组1年累积复发率及无复发生存率(RFS)、1年累积远处转移率及无远处转移生存率(MFS)分别为9.1%、90.9%、12.1%、87.9%,对照组分别为9.4%、90.6%、15.6%、84.4%,两组比较无统计学差异。对照组Ⅲ～Ⅳ级粒细胞毒性、口腔黏膜反应及胃肠道反应分别为25.0%、28.1%、25.0%,较治疗组的3.0%、6.1%、3.0%重,差异有统计学意义(P<0.05)。[结论]顺铂单药每周方案给药与每3周方案给药配合同期放疗治疗局部晚期鼻咽癌疗效确切,但每周方案组患者毒副反应较每3周方案组轻,耐受性更好。

[Purpose] To investigate the short-term effect, toxicity and tolerance of concurrent radiotherapy with cisplatin weekly versus every 3 weeks administration for locally advanced nasopharyngeal carcinoma (NPC). [Methods] Sixty-five cases with locally advanced NPC were randomized into treatment group (n=33) and control group (n=32). The treatment group was received 30mg/m2 DDP weekly, and the control group were received 80mg/m2 DDP every 3 weeks (d1,22,43). Both groups were received the same conventional radio...