湖北地区汉族人群p53基因第72位密码子多态性与宫颈鳞癌相关性

Correlation between p53 Codon 72 Polymorphism and Cervical Squamous Cell Carcinoma in Chinese Han Population in Hubei Area

[目的]探讨p53基因第72位密码子多态性与湖北地区汉族人群宫颈癌相关性。[方法]采用PCR法检测104例宫颈鳞癌及84例正常宫颈组织标本中p53基因第72位密码子的基因型。[结果]p53基因第12位密码子的3种基因型Arg/Arg、Arg/Pro、Pro/Pro在宫颈鳞癌组比例分别为38.5%、44.2%和17.3%;对照组中分别为52.4%、40.5%和7.1%。Pro/Pro基因型在宫颈鳞癌组中所占比例显著高于正常宫颈组织(P=0.018)。[结论]p53基因第72位密码子Pro/Pro基因型是湖北地区汉族女性发生宫颈鳞癌的遗传易感因素之一。

[Purpose] To investigate the correlation between p53 codon 72 polymorphism and cervical carcinoma in Chinese Han population in Hubei area. [Methods] p53 codon 72 polymorphism in 104 cases with cervical squamous cell carcinoma (SCC) and 84 cases with normal cervical tissue were detected by immunohistochemical method. [Results] The proportion of p53 codon 72 gene type Arg/Arg, Arg/Pro and Pro/ Pro was 38.5%, 44.2% and 17.3% in SCC group, and 52.4%, 40.5% and 7.1% in control group respectively. The proportion ...