摘要
[目的]探讨三阴性乳腺癌的临床病理特征、复发及预后。[方法]回顾性分析2000年7月至2006年7月手术治疗的486例乳腺癌患者资料。将ER、PR、HER-2均为阴性患者定义为三阴性乳腺癌组,其他患者定义为非三阴性乳腺癌组。采用免疫组化法检测ER、PR、HER-2的表达,随访观察患者的生存情况。74例(15.2%)符合三阴性乳腺癌诊断标准。[结果]与非三阴性乳腺癌组比较,三阴性乳腺癌组绝经前患者比例升高,组织学分级较高。三阴性乳腺癌组5年无病生存率、5年总生存率均低于非三阴性乳腺癌组(P=0.038,P=0.014)。且三阴性乳腺癌患者更容易出现内脏转移(P=0.024),复发后生存时间更短(P=0.000)。[结论]三阴性乳腺癌患者有着特殊的临床病理特征,易出现复发转移(尤其是内脏转移),预后差。
[Purpose] To investigate of the clinical pathological features, recurrence and prognosis of triple-negative breast cancer. [Methods] From July 2000 to July 2006, 486 cases of breast cancer with surgical treatment were analyzed retrospectively. The triple-negative breast cancer is defined as negative expression of estrogen receptor(ER), progesterone receptor (PR) and HER-2, and the other cases were non-triple-negative. The expression of ER, PR and HER-2 were detected by immunohistochemical method. All the ca...
出处
《肿瘤学杂志》
CAS
2009年第11期1005-1008,共4页
Journal of Chinese Oncology
关键词
乳腺肿瘤
ER
PR
HER-2
预后
breast neoplasms
triple-negative
clinical pathology
prognosis
