摘要
目的探讨内皮细胞功能和血小板活化状态在脊髓缺血再灌注损伤(SCI/RI)中的意义。方法采用Zivin法建立家兔SCI/RI模型,动态观察SCI/RI前后血浆一氧化氮(NO)和血小板α颗粒膜蛋白140(GMP140)的变化。结果NO在I/R组缺血末期显著上升(P<0.01),I/R2h达到峰值,与sham组比较有显著意义(P<0.01);I/R6h下降但仍有显著差异(P<0.05);GMP-140在sham组无显著变化,在I/R组缺血末期显著升高(P<0.01),I/R2h后逐渐下降到正常水平。结论血浆NO和GMP140在SCI/RI后显著升高,表明内皮细胞受刺激/损伤和血小板过度活化参与了脊髓I/R损伤与修复病理过程。
Objective To study the changes of vascular endothelial cell function and platelet activation in rabbit spinal cord following ischemia-reperfusion (I/R) injury and their roles in the spinal cord injury. Methods Rabbit spinal cord I/R injury models were established using Zivin method, and the changes in plasma NO and GMP140 levels were dynamically monitored after the injury. Results Plasma NO level increased significantly in the I/R group at the end of the ischemia, and reached the peak level at 2 h of reperf...
出处
《南方医科大学学报》
CAS
CSCD
北大核心
2009年第8期1638-1640,共3页
Journal of Southern Medical University
关键词
脊髓
缺血再灌注
内皮细胞功能
血小板活化
一氧化氮
α颗粒膜蛋白140
spinal cord
ischemia/reperfusion
vascular endothelial function
platelet activation
nitric oxide
granule membrane protein140
