抗环瓜氨酸肽抗体检测对类风湿性关节炎的诊断价值

The value of anti-cyclic citrullinated peptides antibody in diagnosis of rheumatoid arthritis

目的探讨抗环瓜氨酸多肽抗体(CCP-Ab)与类风湿因子(RF)在类风湿性关节炎(RA)诊断中的临床价值。方法使用酶标分析仪及其IgG ELISA试剂盒检测血清抗CCP-Ab;采用基于速率散射比浊法的BN100特定蛋白仪测定血清RF。结果130例RF阳性病例RF最大值640.00 IU/ml,最小值20.26 IU/ml,均值95.63 IU/ml;抗CCP-Ab检测RA的特异度较RF高,差异具有显著性意义(P<0.05)。结论血清RF和抗CCP-Ab是RA良好的诊断指标,二者联合检测有助于RA的早期诊断、预后判断和治疗观察。

Objective To evaluate the relationships between anti-cyclic citrullinated peptides(CCP) antibody and rheumatoid factors(RF),and explore its diagnostic value in rheumatoid arthritis(RA).Methods Serum anti-CCP antibody was detected by IgG ELISA Reagent Kit,and RF was examined by BN100 specific protein analyzer.Results In 130 cases of RF positive,the maximum value was 640.00 IU/ml,the minimum value was 20.26 IU/ml,and the average value was 95.63 IU/ml.Specificity of anti-ccp Ab to RA is higher than that of RF....