门冬氨酸鸟氨酸联合易善复治疗非酒精性脂肪性肝炎临床观察

Effects of Ornithine Aspartate combined with Essentiale N on nonalcoholic steatohepatitis

目的观察门冬氨酸鸟氨酸联合易善复对非酒精性脂肪性肝炎的临床疗效。方法非酒精性脂肪性肝炎患者70例,随机分成两组,治疗组采用门冬氨酸鸟氨酸静脉给药(剂量为10 g/次,1次/d)联合易善复口服治疗(456 mg/次,3次/d),对照组仅采用易善复治疗(用法用量同治疗组),于治疗前及治疗4周后观察患者血清谷丙转氨酶、谷草转氨酶、甘油三酯、胆固醇变化,4周后B超观察肝脏形态变化。结果两组患者于治疗前后实验室指标均有明显改善,但治疗组明显优于对照组(P<0.05);4周后治疗组肝脏声像形态评分要明显优于对照组(P<0.05)。结论门冬氨酸鸟氨酸联合易善复治疗非酒精性脂肪性肝炎具有较好的临床疗效,值得进一步研究。

Objective To investigate the clinical effect of Ornithine Aspartate combined with Essentiale N on nonalcoholic steatohepatitis(NASH). Methods Seventy patients who suffered from nonalcoholic steatohepatitis,were randomly divided into treatment group and control group.Patients in treatment group were treated with Ornithine Aspartate and Essentiale N,while patients in control group were treated only with Essentiale N.Before and after four weeks treatment,hepatic functions,triglyceride and cholesterol in serum ...