普罗布考类药物在治疗酒精性脂肪肝中的作用

The effect of Probucol on alcoholic fatty liver

目的探究普罗布考类药物在治疗酒精性脂肪性肝病中的作用,为临床应用普罗布考类药物治疗酒精性脂肪性肝病提供理论依据。方法构建酒精性脂肪性肝病大鼠模型。Wister大鼠普通饲料喂养1周后,随机分为空白对照组(12只)、实验组(24只)。空白对照组喂养普通饲料,实验组喂养普通饲料的同时加入酒精,5周后将实验组再随机分为药物组(12只,普罗布考,剂量1 mg/kg),非药物组(12只),共治疗5周。实验结束后,比较各组大鼠肝肿大程度、血清ALT、肝组织病理学评分。结果普罗布考明显减轻肝肿大(P<0.05),降低血清ALT(P<0.01),肝组织病理改善明显(减轻脂肪变性程度,P<0.01;减少小叶炎症数,P<0.001;减轻肝细胞气球样变性,P<0.05)。结论普罗布考在治疗大鼠酒精性脂肪肝中有效。

Objective To study the effect of Probucol on alcoholic fatty liver,and to provide the theoretical basis for its clinical application.Methods After fed with animal feeds for one week,thirty-six Wister rats were randomly divided into experimental group(24) and control group(12).The rats in control group were fed with ordinary feeds.The rats in the experimental group were fed with alcohol for 5 weeks to construct the model of alcoholic fatty liver.Twelve rats in the experimental group were interfered by Probue...