一个新的心血管疾病标志物——心锚重复蛋白

Cardiac Ankyrin Repeat Protein——a Novel Marker of Cardiovascular Disease

心锚重复蛋白属于锚蛋白重复序列蛋白家族成员,是一个核转录辅助因子,在转录过程中起辅助激活物和辅助阻遏物的作用。心锚重复蛋白受Nkx2.5、转化生长因子-β/Sm ad、p38丝裂原激活的蛋白激酶等多条信号通路调节,在心脏生长发育、血管新生、细胞凋亡、维持心肌结构和功能的完整性、心肌肥厚、动脉粥样硬化和心律失常等多方面发挥作用。

Cardiac ankyrin repeat protein,a nuclear transcription cofactor,as a co-activator and co-repressor in the transcription process,belongs to a conserved gene family of muscle ankyrin repeat proteins.Cardiac ankyrin repeat protein,regulated by Nkx2.5,transforming growth factor-β/Smad,p38 mitogen-activated protein kinase,and other signaling pathways,plays a role in heart development,neovascularization,apoptosis,sustaining the integrity of myocardial structure and function,myocardial hypertrophy,artherosclerosis...