心肌梗死后交感神经重构的研究进展

Progress in Sympathetic Remodeling after Myocardial Infarction

心肌梗死后心脏交感神经分布改变,使去神经支配和神经过度支配区域共存,引起电生理异质性增加。交感神经重构和电重构相互影响,成为心肌梗死后恶性心律失常发生和猝死的重要因素。交感神经重构的机制和干预已经成为研究的热点问题,可能为将来心肌梗死后心律失常的治疗提供一个新的方向。

The distribution of cardiac sympathetic nerve changes after myocardial infarction.The regional co-existence of denervation and excessive innervation increases electrophysiological heterogeneity.Sympathetic remodeling and electrical remodeling influences mutually,which becomes an important factor of malignant arrhythmia and sudden death after myocardial infarction.The mechanisms and intervention of sympathetic remodeling have become a hot issue,which may be offer a new direction for the therapy of arrhythmia...