摘要
采用反相悬浮法制备交联壳聚糖微球,再与α-酮戊二酸反应生成Schiff碱,以NaBH4还原制得改性壳聚糖微球。用FT-IR,SEM和XRD进行表征。并以来氟米特(LEF)为模型药物,考察了其缓释效果。结果显示:微球对药物的最大包封率为94%,载药量为62%,在缓释初期2h内微球平均释放药量的16%,后期则呈现缓慢释放的趋势。本论文采用的微粒的药物承载量和释放速度既保证了药物的药效又降低了药物释放速率过快引起的对人体的不良反应。
Chitosan microspheres were prepared by inverse phase suspension method.The Chitosan was modified by reducing Schiff’s bases formed from the reaction of α-ketoglutaric acid Chitosan.The structure of microspheres was characterized by FT-IR,SEM and XRD.Leflunomide(LEF) was taken as the typical drug to determine the controlled release in vitro.Results from tests indicate the highest encapsulation efficiency and load of LEF reached to 94%and 62% respectively.Modified Chitosan microspheres released 16%of LEF in a...
出处
《天然产物研究与开发》
CAS
CSCD
2010年第2期289-292,共4页
Natural Product Research and Development
关键词
壳聚糖
微球
来氟米特
缓释
Chitosan
microsphere
leflunomide（LEF）
controlled release
