一种提高双氢青蒿素电化学检测分辨率的新方法

A new method for improving the electrochemical resolution of dihydroartemisinin

采用电化学方法研究了阳离子表面活性剂对双氢青蒿素(DHA)在银电极表面伏安行为的影响,并探讨了其电极界面的电化学机理。随着阳离子表面活性剂十六烷基三甲基溴化铵(CTMAB)的加入,DHA的还原峰电位发生明显的变化。当CTMAB的浓度为1.0×10-5mol/L时,DHA的峰电位正移了102 mV,活化能降低,DHA的过氧键更容易断裂。当CTMAB的浓度继续增大至7.0×10-4mol/L,DHA的峰电位负移了108 mV,活化能增大,DHA的过氧键更稳定。同时,还研究了酸度、温度和不同结构的阳离子表面活性剂对DHA伏安行为的影响,并提出其作用机制,从而建立一种提高DHA电化学检测分辨率的新方法。

Surfactants can improve the electrochemical responses of compounds effectively,resulting in enhancements of the resolution and selectivity.The objective of the present work is to investigate the effects of cationic surfactants on the voltammetric behavior of dihydroartemisinin(DHA) by using electrochemical methods and explore the mechanism at a silver electrode interface.The results show that the redox peak potential of DHA obviously changes as increasing the concentration of hexadecyltrimethylammonium brom...