老年高血压患者颈动脉粥样硬化与超敏C反应蛋白的关系

Analysis of Relationship between High-sensitivity C-reactive Protein and Carotid Atherosclerosis in Hypertensive Patients

目的研究老年高血压病合并颈动脉粥样硬化的患者血清超敏C反应蛋白(high-sensitivity C-reactive protein,hsCRP)的变化,探讨2者之间的相关性。方法对首都医科大学附属北京天坛医院就诊的95例老年高血压患者进行颈动脉超声检查,测量颈总动脉内中膜厚度(intimal-medial thickness,IMT),观察有无颈动脉斑块形成,判断有无颈动脉粥样硬化,同时进行血清hsCRP浓度的测定。分析血清hsCRP与颈动脉粥样硬化、颈总动脉内中膜厚度及颈动脉斑块形成之间的关系。结果合并颈动脉粥样硬化的老年高血压患者血清hsCRP明显高于无颈动脉硬化的老年高血压患者且差异有统计学意义(P=0.007)。结论老年高血压病合并颈动脉粥样硬化尤其是颈动脉斑块患者的血清hsCRP显著高于无颈动脉病变者,说明血清hsCRP与老年高血压病患者颈动脉粥样硬化的发生有一定相关性,炎性反应可能参与了高血压病颈动脉粥样硬化的形成。

Objective To study the relationship between serum high-sensitivity C-reactive protein(hsCRP) level and carotid atherosclerosis in elderly patients with essential hypertension.Methods The serum concentrations of high-sensitivity C-reactive protein(hsCRP) were measured in ninety-five elderly patients with essential hypertension.A color doppler ultrasound system was used to investigate the intimal-medial thickness(IMT) of common carotid artery(CCA) and the plaque of carotid artery.Results Serum hsCRP was signi...