摘要
目的研究渗透吸收促进剂氮酮用量对莫诺苯宗乳膏体在外经皮渗透的影响,并拟定氮酮的最佳浓度。方法以30%乙醇-水溶液为接收液,小鼠离体皮肤为屏障,采用改良的Franz扩散池进行体外渗透实验,HPLC法测定接收液中莫诺苯宗的含量。结果24h内,不同浓度的氮酮对莫诺苯宗乳膏透皮吸收均有一定的促进作用,其促渗作用为2%氮酮>5%氮酮>1%氮酮>0氮酮。结论氮酮能促进莫诺苯宗乳膏中莫诺苯宗的透皮吸收,以2%的氮酮促透效果最佳。
OBJECTIVE To explore the influence of azone upon the percutaneous permeability of monobenzone cream in vitro.METHODS 30% ethanol-water solution as acceptor,the permeability test was made on the off-body skins of mice in Franz diffusion cell,and the penetration quantity of monobenzone in acceptor was measured by HPLC.RESULTS The release rate of monobenzone was different by adding various proportion of Azone,and the release rate of the monobenzone was 2% azone > 5% azone > 1% azone > 0 azone.CONCLUSI...
出处
《华西药学杂志》
CAS
CSCD
北大核心
2010年第2期151-153,共3页
West China Journal of Pharmaceutical Sciences
关键词
氮酮
莫诺苯宗乳膏
透皮吸收
离体
Azone
Monobenzone cream
Transdermal absorption
In vitro