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Design and synthesis of DPP-4 inhibitor for the treatment of type 2 diabetes 被引量：3

Design and synthesis of DPP-4 inhibitor for the treatment of type 2 diabetes
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摘要 An efficient stereoselective synthesis of the rigid aza-bicyclo[3.2.0]heptane scaffold has been developed to provide 2-cyano-pyrrolidine alpha-amino amide 1 as DPP-4 inhibitor. An efficient stereoselective synthesis of the rigid aza-bicyclo[3.2.0]heptane scaffold has been developed to provide 2-cyano-pyrrolidine alpha-amino amide 1 as DPP-4 inhibitor.
作者 Peng Cho Tang
机构地区 Shanghai Hengrui Pharmaceuticals Co.Ltd.
出处 《Chinese Chemical Letters》 SCIE CAS CSCD 2010年第3期253-256,共4页 中国化学快报（英文版）
关键词 DPP-4 inhibitor Aza-bicyclo[3.2.0]heptane scaffold 2-Cyanopyrrolidine alpha-amino amide derivative SYNTHESIS Type 2 diabetes DPP-4 inhibitor Aza-bicyclo[3.2.0]heptane scaffold 2-Cyanopyrrolidine alpha-amino amide derivative Synthesis Type 2 diabetes
分类号 TQ464 [化学工程—制药化工]
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参考文献10

  • 1D.J.Augeri,J.A.Robl,D.A.Betebenner,et al. Journal of Medicinal Chemistry . 2005
  • 2L.A.Joao Carlos,A.S.Regina Helena de,R.D.C.Carlos. J.Braz.Chem.Soc . 2003
  • 3J.S.Rosenblum,J.W.Kozarich. Current Opinion in Chemical Biology . 2003
  • 4Zander M,Madsbad S,Madsen JL,et al.Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and beta-cell function in type 2 diabetes: a parallel-group study. The Lancet . 2002
  • 5Gautier,J.F.,Fetita,S.,Sobngwi,E.,Salaun-Martin,C.Biological actions of the incretins GIP and GLP-1 and therapeutic perspectives in patients with type 2 diabetes. Diabetes and Metabolism . 2005
  • 6Gwaltney SL,Stafford JA.Inhibitors of dipeptidyl peptidase4. Annual Reports in Medicinal Chemistry . 2005
  • 7Villhauer EB,Brinkman JA,Naderi GB,et al.1-[[(3-Hydroxy-1- adamantyl) amino]acetyl]-2-cyano-(S)-pyrrolidine:a potent, selective,and orally bioavailable dipeptidyl peptidaseⅣinhibitor with anti-hyperglycemic properties. Journal of Medicinal Chemistry . 2003
  • 8PETERS J U.11Years of cyanopyrrolidines as DPP.Ⅳinhibitors. Current Topics in Medicinal Chemistry . 2007
  • 9Magnin DR,Robl JA,Sulsky RB,et al.Synthesis of novel potent dipeptidyl peptidase IV inhibitors with enhanced chemical stability:interplay between the N-terminal amino acid alkyl side chain and the cyclopropyl group ofα-aminoacyl-l-cis-4,5-methanoprolinenitrile-based inhibitors. Journal of Medicinal Chemistry . 2004
  • 10Lankas GR,Leiting B,Roy RS, et al.Dipeptidyl peptidase IV Inhibition for the treatment of type 2 diabetes potential importance of selectivity over dipeptidyl peptidases 8 and 9. Diabetes . 2005

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二级引证文献19

Chinese Chemical Letters
2010年 第3期

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