摘要
DNA photocleavage properties of halogenated mono-hydroxyl corrole 1-5 were investigated.It was found that these corroles were able to photocleavage supercoiled pBR 322 DNA（SC） into nicked-circular DNA（NC）.The activity of these corroles follows an order of 4>3>2≈1>5.The photosensitized singlet oxygen（Φ;） quantum yield by these corroles also follows that same order,showing the photocleavage activity is related to the heavy atom effect of halogen atoms on corroles.
DNA photocleavage properties of halogenated mono-hydroxyl corrole 1-5 were investigated.It was found that these corroles were able to photocleavage supercoiled pBR 322 DNA(SC) into nicked-circular DNA(NC).The activity of these corroles follows an order of 4>3>2≈1>5.The photosensitized singlet oxygen(Φ_△) quantum yield by these corroles also follows that same order,showing the photocleavage activity is related to the heavy atom effect of halogen atoms on corroles.
基金
supported by the National Natural Science Foundation of China(Nos.20771039,20625205, 20871122,20971046)
National Key Foundation Research Development Project(973) Item of China(No. 2007CB815306)
