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考虑结核病!肺结核的诊断延误是使用抗生素引起的吗? 被引量:3

Think TB! Is the diagnosis of pulmonary tuberculosis delayed by the use of antibiotics?
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摘要 背景:有效的结核病(TB)控制需要对传染性结核病例进行及早诊断,这需要对所有有呼吸系统症状的患者进行早期的肺结核排查。目的:验证我们的假设:在结核病低发病率的欧洲国家,由于对细菌感染的患者优先使用抗生素治疗,导致结核病诊断延迟。设计:在一个独立的城市中心医院,对通过培养确诊的成年肺结核患者进行评价,研究抗生素治疗对症状改善和抗结核治疗起始时间的影响。结果:83例患者中,42例(51%)在诊断结核病之前使用了抗生素,其中20例(48%)患者症状得到改善,这与药物类别无关。虽然接受抗生素治疗的患者诊断周期的中位数延长(P=0.001),但对治疗结果并没有预测性提示。在94%的患者中,最初胸部X线提示有结核感染。结论:结核病诊断前的抗生素治疗,使患者遭受与诊断过程有关的治疗延误。为最大程度降低结核病传播,我们建议临床医生应将结核病包括在最初的鉴别诊断中,在诊断过程初期对有呼吸道症状的患者进行简单的结核病相关检查。
出处 《国际结核病与肺部疾病杂志》 2010年第1期5-9,共5页 The International Journal of Tuberculosis and Lung Disease
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参考文献32

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