摘要
目的探讨无抽搐电休克(MECT)治疗前后抑郁障碍患者非匹配负波(MMN)的特点。方法应用脑诱发电位仪,对31名正常人和33例抑郁障碍患者在MECT治疗前后进行了MMN检测。结果与正常对照组比较,抑郁障碍组的MMN潜伏期延迟和波幅降低[分别(202.1±32.1)ms和(8.0±3.8)μV,(224.3±35.0)ms和(5.6±3.5)μV,P均<0.01];抑郁障碍组P300中的靶指标P3潜伏期延迟、靶波幅P3降低(分别P<0.01和P<0.05)。抑郁障碍组经MECT治疗后的MMN波幅低。结论 MMN和P300联合应用可作为MECT治疗抑郁障碍监测的有临床意义的指标。
Objective To investigate the effect of modified electroconvulsive therapy (MECT) on mismatch negativity(MMN) in patients with depression.Methods Using brain evoked potential instrument,the MMN was recorded in 31 normal controls(NC) and 33 depressive patients before and after MECT.Results Compared with NC,the depressive patients showed delayed MMN latency [NC(202.1±32.1)ms,the depression group(224.3±35.0)ms,P<0.01],decreased MMN amplitude [NC(8.0±3.8)μV,the depression group (5.6±3.5)μV,P<0.01],delayed ...
出处
《神经病学与神经康复学杂志》
2009年第4期274-276,共3页
Journal of Neurology and Neurorehabilitation
关键词
抑郁障碍
非匹配负波
无抽搐电休克
depression
mismatch negativity
modified electroconvulsive therapy
