抗心肌缺血药物治疗进展

Progress of anti-ischemic medications

心肌缺血是指心肌耗氧量和冠状动脉供血、供氧之间不平衡而导致的心肌损害。心肌耗氧量增加或供氧减少都可引发心肌缺血。抗心肌缺血药物可以通过减少心肌耗氧量或增加心肌供氧而减少心绞痛的发作。目前常用的抗心肌缺血药物包括硝酸酯类药物、β受体阻断剂、钙拮抗剂和改善心肌代谢的药物等。临床可以依据不同的病因选择不同作用机制的药物。

The imbalance between myocardial oxygen supply and myocardial oxygen demand is viewed as the pathophysiological basis of myocardial ischemia.Any factor that causes an increase in myocardial oxygen demand or a reduction in myocardial oxygen supply can provoke ischemia.Anti-ischemic medications eliminate or reduce angina by decreasing myocardial oxygen demand,increasing myocardial oxygen supply,or both.The commonly used anti-ischemic medications include nitrates,beta-blockers,calcium antagonist and drugs used...