葡膦酰胺静脉给药对比格犬的毒性作用

Toxicity of glufosfamide in Beagle dogs following intravenous injection

目的:评价葡膦酰胺对比格犬的安全性。方法:观察葡膦酰胺单次静脉注射和连续静脉注射3个月对比格犬的毒性作用。结果:葡膦酰胺单次静脉注射比格犬最低致死剂量为100 mg/kg,最高非致死剂量为50 mg/kg,近似致死剂量范围为75～100 mg/kg。连续静脉注射20,40,60 mg/kg,每周1次,连续3个月,无严重不良反应症状,但组织病理学检查发现中、高剂量组出现广泛组织脏器损伤,低剂量组个别脏器出现轻微病理改变。结论:在本实验条件下,40,60 mg/kg剂量葡膦酰胺每周1次,连续3个月静脉给药可造成比格犬广泛的脏器损伤。每周1次,连续3个月静脉给药剂量应低于20mg/kg。

Aim:To evaluate the safety of glufosfamide in Beagle dogs.Methods:The safety of glufosfamide in Beagle dogs following single iv and multiple iv administration for 3 months was observed.Results:The minimum lethal dose of glufosfamide was 100 mg/kg.The maximum non-lethal dose of glufosfamide was 50 mg/kg.The approximate lethal dose of glufosfamide was 75-100 mg/kg.No serious adverse reactions was observed in Beagle dogs following multiple iv administration once a week for 3 months at the dose of 20 mg/kg,40 m...