面心设计——效应面法优化巴布剂基质的研究

Optimization of cataplasm matrix with face-centered design-response surface method

目的:优化巴布剂基质处方。方法:采用面心设计,考察自变量卡波姆、聚丙烯酸钠、交联剂等因素对因变量初黏力的影响,拟合二次多项式方程,结合效应面法,优选较佳处方,并进行预测分析。结果:二次多项式拟合方程复相关系数R2=0.970,Ad j-R2=0.952,方差分析F四归=53.953,P=0.000 1,模型高度显著;效应面法分析确定了巴布剂基质较佳处方,验证实验结果满意。结论:面心设计-效应面法应用于巴布剂基质的优化,方法简便,预测性良好。

Objective:To optimize the matrix formulation of cataplasm.Method:Face-centered design was used in the experimental design,and response surface was produced in quadratic polynomial after data fitting in order to explore the impacts of Sodium Polyacrylate,Carbomer and the cross-linking agent on stickiness of cataplasm,optimize the prescription of the cataplasm matrix and perform the evaluation analysis.Result:The multiple correlation coefficient(R2) and adjusted R2 in the fitting method using quadratic polyno...