滇杠柳的化学成分及其细胞毒活性筛选(英文)

Chemical constituents of Periploca forrestii and their cytotoxicity activity

目的:研究滇杠柳Periploca forrestii的化学成分并筛选其细胞毒活性。方法:利用色谱技术进行分离和纯化,并通过现代谱学方法鉴定其结构,对分离得到的化合物2-4用血液系统肿瘤(HL-60,CCRT-CEM),前列腺肿瘤(PC-3,DU-145)以及黑色素瘤(UACC-62)等细胞系细胞进行细胞毒活性筛选。结果:从滇杠柳中分离鉴定了4个化合物。分别为upeol-20(29)-en-3-nonadecanoate(1),peroiforoside(2),3β,5β,14β-3OH-8β-H-car-20(22)-enolide(3),perplocin(4)。结论:其中化合物1是新化合物,化合物2~4有一定的细胞毒活性。

Objective:To investigate the chemical constituents of the roots of Periploca forrestii and evaluate their cytotoxicity activities.Method:Silica gel column chromatography was employed for the isolation and purification of chemical constituents.The structures were identified on the basis of spectral data and the cytotoxicities of compounds 2-4 were investigated by several tumors cell lines including blood tumor(HL-60,CCRT-CEM),prostate tumor(PC-3,DU-145) and Melanoma(UACC-62).Result:Four compounds were isolat...