摘要
[目的]通过对非小细胞肺癌患者进行不同抗癌药物肿瘤ATP化疗药物敏感性(ATP-TCA)实验,以期寻找个体化的化疗用药方案。[方法]72例非小细胞肺癌患者,其中37例(药敏实验组)标本应用三磷酸腺苷生物荧光法(ATP法)检测8种抗癌药物的敏感性,根据实验结果选用敏感药物对患者进行辅助化疗;另35例患者(经验对照组)为同期按经验选用NP方案(长春瑞滨+顺铂),比较药敏实验组与经验对照组化疗后临床效果的差异。[结果]ATP-TCA实验对非小细胞肺癌标本可评估率为94.59%,临床有效率为62.86%,敏感性为95.45%,特异性为38.46%,总预测准确率为74.29%,阳性预测值为72.41%,阴性预测值为83.33%。药敏实验组临床有效率为62.86%,经验对照组临床有效率为34.29%(χ2=5.72,P<0.05)。[结论]ATP-TCA是一种有效的化疗药物敏感性分析实验,对指导非小细胞肺癌患者个体化化疗有重要的临床意义。
[Purpose] To investigate the individualized chemotherapy protocol which can be applied in clinical chemotherapy for non-small cell lung cancer (NSCLC) conducted with the ATPbased tumor chemosensitivity assay (ATP-TCA). [Methods] Among 72 cases with NSCLC, 37 cases (trial group) suffered from 8 kinds of anti-cancer drugs and the sensitivity for each drug was detected with ATP-TCA. According to the experiment results, for each patient of trial group there would be some special sensitive drugs selected for adj...
出处
《肿瘤学杂志》
CAS
2009年第12期1076-1079,共4页
Journal of Chinese Oncology
关键词
癌
非小细胞肺
ATP-TCA
抗肿瘤药
药物疗法
cancer
non-small cell lung
ATP-based tumor chemosensitivity assay
anti-tumor drugs
drug therapy
