老年急性脑梗死患者红细胞免疫功能与 C 反应蛋白的探讨

The change of RBC immunity and C-reactive protein in elderly patients with acute cerebral infarction

目的探讨老年急性脑梗死患者红细胞免疫功能与 C 反应蛋白(C—reachtive protein,CRP)的变化及临床意义。方法应用“郭峰改变法”和透射比浊法分别检测41例老年急性脑梗死患者外周血红细胞 C3b 受体花环率(RBC-C3bRR)、红细胞免疫复合物花环率(RBC-ICR)和 CRP 的含量,并随机在同期的32例健康老年人作对照。结果老年急性脑梗死组 RBC-C3bRR 明显低于对照组:RBC-ICR 和 CRP 则明显高于对照组,两组比较均有显著性差异(P<0.01)。RBC-ICR 与 CRP 呈正相关(r=0.67,P<0.01)。结论老年急性脑梗死患者存在严重的红细胞免疫功能低下,炎症反应是急性脑梗死发病中的一个重要因素,并影响该病的发生、发展和预后。因此提高细胞免疫功能,终止和减轻炎症反应,可降低老年急性恼梗死发病的危险性。

To investigate the RBC immunity and C-reactive protein(CRP)change in elderly patients with cerebral infarction and to discuss their clinical significance.Methods RBCs from peripheral blood of 41 elderly patients with acute cerebral infarction were tested for the rates of RBC-C3b rosette receptor(RBC- C3bRR)and RBC immune complex rosette(RBC-ICR)as well as the level of CRP by using Guo Feng's re- vised method and transmission turbidimetry.32 healthy elderly subjects served as control.Results RBC— C3bRR was apparently lower but RBC-ICR and CRP were apparently higher in the cerebral infarction group than those in the control group.The differences between the two groups were statistically significant(P< 0.01).RBC-ICR was positively correlated with CRP(r=0.67,P<0.01).Conclusions There is seri- ous impairment of RBC immunity in elderly patients with acute cerebral infarction,Inflammatory reaction is an important factor not only in the pathogenesis of acute cerebral infarction but also in its development and cure. Therefore,enhancement of cellular immunity and stop or amelioration of inflammatory reaction may decrease the risk of acute cerebral infarction.