反向流动注射化学发光法测定马来酸氯苯那敏

Reversed-phase flow-injection chemiluminescence determination of chlorphena mine maleate

基于马来酸氯苯那敏对KIO4-鲁米诺化学发光体系有强的增敏作用,结合反向流动注射技术,建立了测定马来酸氯苯那敏的化学发光分析方法,在优化的条件下,测定马来酸氯苯那敏的线性范围为7.0×10-8~1.0×10-4g/mL,检出限为3×10-8g/mL,对质量浓度为9.0×10-7g/mL的马来酸氯苯那敏进行11次平行测定,其相对标准偏差为1.5%,方法已用于扑儿敏片剂和人体尿液中马来酸氯苯那敏的含量测定。

A highly sensitive chemiluminescence(CL) method for the determination of chlorphena mine maleate by reversed-phase flow-injection analysis has been developed based on enhancement of the CL intensity of KIO4-Luminol-NaOH system by chlorphena mine maleate.The relationship between the CL intensity and the concentration of chlorphena mine Maleate is linear in the range of 7×10-8～1×10-4 g/mL.The realative standard deviation was 1.5%(n=11,ρ=9.0×10-7 g/mL).The detection limit of chlorphena mine maleate was 3×10-8 g/mL.The method has been applied to the determination of chlorphena mine maleate in tablets and urine.