大面积深度烧伤后保痂患者早期短程使用广谱高效抗生素的疗效

Administration of highly effective antibiotics in the early stage of severe burn patients

目的 探讨大积积深度烧伤后保痂患者广谱高效抗生素早期短程使用的效果。方法 同一时期收治的14名大面积深度烧伤患者(深Ⅱ度加Ⅲ度面积>50％),且都因各种原因未行早期切痂植皮。随机分成两组,抗生素短程用药组和传统用药组,比较在全身使用泰能和丁胺卡那霉素情况下两组的抢救成功率,血中细菌培养以及体温、白细胞总数、血小板计数等与感染密切相关的指标之间的差别。结果 14名患者均成活,且无一例血培养细菌阳性者,两组的体温、白细胞总数、血小板计数均无显著性差异(P>0.05)。结论 观察结果表明,对于大面积深度烧伤后保痂治疗的患者,早期短程应用广谱高效抗生素冲击治疗的优点是明显的,既有效地预防了全身感染,又节省了费用。

Objective To evaluate the effect of early use of highly effective antibiotics in short course following no-surgery severe burn. Methods Fourteen no-surgery sever burn patients hospitalized in same period were randomly divided into two groups: the early use of highly effective antibiotic (Imipenum and amikacin) in short course and traditionally use of highly effective antibiotic as control. The survival rate, blood culture, body temperature as well as white blood cell and platelet count of the two groups were compared. Results Fourteen patients were all survived. No one showed having positive bacterial blood culture. There was no significant statistics difference showed in body temperature, WBC and platelet counts between the groups (P>0. 05). Conclusions The results manifest the early application of highly effective antibiotics for a short course having obvious benefit to the severe burn cases not subjected to early eschar removal in preventing systemic infection and reducing the cost of treatment.