2-氨基-6-硝基苯并噻唑的合成研究

The Synthesis of 2-Amino-6-Nitrobenzothiazole

以工业级对硝基苯胺和硫氰酸铵为原料,在催化剂的作用下,两步反应合成2-氨基-6-硝基苯并噻唑。实验表明最佳工艺条件:对硝基苯胺:硫氰酸铵:苯=1:1.15:6.5,反应温度为80～85℃,反应时间为10h,对硝基苯基硫脲:催化剂=1:0.093,室温反应,反应时间为2h。在上述工艺条件下产品的总收率64.5％,纯度≥99％。

The 2 - amino -6 - nitrobenzothiazole is synthesized fromP- nitroanilinum of technical grade by catalyst, It isdemonstrated by experiment that the optimum technological conditions are:p - nitroanilinum: amthio: beneze = 1: 1. 15:6.5; reac-tion temperature:80～ 85℃; response time: 10 hours; p -nitrothenylthiourea: catalyst = 1:0.093. room -temperature reaction,time:2 hours. Under the above - mentiened conditions, the total recovery reaches 64.5%, with its purity≥99%.