微量营养素对人类免疫缺陷病毒感染者免疫状态的影响

Effect of Micronutrients on the Immune Status of Human Immunodeficiency Virus-positive Individuals

目的研究微量营养素对人类免疫缺陷病毒(HIV)感染者体内免疫状态的影响。方法将102名HIV感染者分为对照组和试验组,分别给予安慰剂和复合微量营养素片,在研究开始及结束时分别进行体格测量和免疫状态测定。结果两组受试者在年龄、身高、体重和男女性别比方面差异没有统计学意义(P均>0.05)。研究前两组受试者体内的CD3+、CD4+、CD8+T淋巴细胞水平和IgA、IgG、IgM、C3水平差异没有统计学意义(P均>0.05);研究后试验组CD3+、CD4+、CD8+T淋巴细胞水平和IgA、IgG、IgM、C3水平均明显高于研究前和对照组(P均<0.05),对照组与研究前差异无统计学意义(P均>0.05)。结论补充微量营养素能改善HIV感染者的细胞和体液免疫功能。

Objective To evaluate the effect of micronutrients on the immune status of human immunodeficiency virus(HIV)-positive individuals.Methods Totally 102 HIV-positive individuals were randomly divided into supplementation group(received micronutrients supplement) and control group(received placebo).Physical examinations were performed at baseline and at the end of the trial.Immune status were determined in both two groups.Results Age,height,weight,and sex ratio were not significantly different between two groups(all P>0.05).Baseline CD3+,CD4+,and CD8+ T lymphocytes and IgA,IgG,IgM,C3 levels were not significantly different between two groups(all P>0.05),while the levels of CD3+,CD4+,and CD8+ T lymphocytes and IgA,IgG,IgM,C3 were significantly higher in supplementation group than in control group(all P<0.05).Conclusion Supplementation of micronutrients can improve the immune status of HIV-positives individuals.