胰岛素样生长因子-1受体在非小细胞肺癌含铂化疗中的意义

Clinical Significance of Insulin-like Growth Factor-1 Receptor in Platinum-based Chemotherapy for Non-small Cell Lung Cancer

目的明确肿瘤组织胰岛素样生长因子-1受体(IGF-1R)表达对晚期非小细胞肺癌化疗疗效及生存的影响。方法采用免疫组织化学的方法对39例初治晚期非小细胞肺癌患者石蜡包埋肿瘤标本进行IGF-1R检测,并分析其与化疗疗效间的关系。结果 53.8%(21/39)的标本检测到IGF-1R的表达。IGF-1R表达与肿瘤病理类型、肿瘤分化程度、吸烟史及吸烟指数均无相关性。IGF-1R不表达者含铂方案化疗效果更好。结论 IGF-1R可能能够预测晚期非小细胞肺癌化疗的疗效。

Objective To explore the influence of the expression of insulin-like growth factor-1 receptor (IGF-1R) in end-stage non-small cell lung cancer.Method The expression of IGF-1R was detected in 39 paraffin-embeded chemotherapy-naive non-small cell lung cancer tumor samples with immunohistochemical method,and the relationship between the outcomes of platinum-based chemotherapy and IGF-1R expression was analyzed.Results IGF-1R expression was detected in 21 cases (53.8%) .The IGF-1R expression status shown no correlation with tumor pathological status,tumor differentiation status,history of smoking,as well as smoking index.Better outcomes of platinum-based chemotherapy were observed in patients with negative IGF-1R expression.Conclusion IGF-1R expression may be used to predict the effectiveness of the first-line platinum-based chemotherapy for end-stage non-small cell lung cancer.