咖啡碱与儿茶素组合对小鼠体重和脂类代谢的影响

Combined Effects of Caffeine and Catechins on the Body Weight and Lipid Metabolism in Mice

采用不同浓度咖啡碱与儿茶素组合粉末饲料喂养小鼠12周,通过称量小鼠体重、脏器及腹腔脂肪(IPAT)等器官重量,测定血清中的生化指标和肝脏中脂类含量的方法,研究不同浓度咖啡碱与儿茶素组合对小鼠体重、脂类代谢的影响。结果表明,所有实验组的小鼠体重增加与对照组相比有下降趋势,其中Ⅳ组(0.06%咖啡碱+0.6%儿茶素)从第4周开始小鼠体重增加显著减少。咖啡碱与儿茶素组合处理的IPAT重量与对照组相比均明显减少。Ⅰ组(0.03%咖啡碱+0.3%儿茶素)、Ⅱ组(0.03%咖啡碱+0.6%儿茶素)可显著降低血清中游离脂肪酸(NEFA)浓度;Ⅲ组(0.06%咖啡碱+0.3%儿茶素)、Ⅳ组(0.06%咖啡碱+0.6%儿茶素)与对照组相比血清总胆固醇(TC)、甘油三酯(TG)与瘦素浓度明显降低;咖啡碱与儿茶素组合能降低肝脏中TC或TG浓度。以上结果表明,绿茶成分咖啡碱与儿茶素组合通过降低血液与肝脏中的脂类含量,可能引起体内脂肪沉积减少,抑制体重增加。

To investigate the combined effects of caffeine and catechins on the body weight and lipid metabolism, mice was with on diets containing different concentration of caffeine and catechins for 12 weeks. Organs and intraperitioneal adipose tissues (IPAT) were weighted at the end of this period. Biochemical parameters in the serum and lipid levels in the liver were measured. The body weight gain was significantly reduced by group Ⅳ(0.06% caffeine+0.6% catechins). Weight of IPAT was remarkable reduced in all exp...