丁苯酞软胶囊联合多奈哌齐治疗血管性痴呆临床疗效观察

Butylphthalide soft capsules joint donepezil treatment of vascular dementia in clinical efficacy

目的评价丁苯酞软胶囊联合多奈哌齐治疗血管性痴呆的疗效及安全性。方法 120例血管性痴呆患者随机分为治疗组和对照组各60例,两组均服用多奈哌齐5mg,1次/晚,治疗组在上述治疗基础上联合应用丁苯酞软胶囊0.2,3次/日,治疗前及治疗90天后应用简易智力状态检查量表(MMSE)和日常生活能力量表(ADL)评定疗效。结果最后能按计划完成治疗和定期随访的患者治疗组57例,对照组58例。治疗组总有效率为86.0%,对照组总有效率为69.0%,两组比较有统计学差异(P<0.05)。治疗组治疗后患者MMSE评分较治疗前明显增加(P<0.05),ADL有明显减低(P<0.05),与对照组比较差异均有统计学意义(P<0.05)。结论丁苯酞软胶囊联合多奈哌齐治疗轻中度血管性痴呆可明显改善患者智能障碍和生活能力,安全性好,优于单用多奈哌齐。

Objective To evaluate the clinical efficacy and safety of combined use of butylphthalide soft capsules and donepezil on the treatment of vascular dementia.Methods 120 patients with vascular dementia were randomly divided into the treatment group and the control group,each had 60 patients.Patients in both groups took donepezil 5mg,once per night.Beside of this,butylphthalide soft capsules were used for the treatment group as a combination,0.2g,3 times per day.Before and after the 90 days’ treatment,Mini-Mental State Examination(MMSE)and Activities of Daily Living scale(ADL)were used to assess the therapeutic effect.Results Fifty-eight cases in the control group and fifty-seven in the treatment group completed the observation and regular follow-up.For the treatment group,the total effective rate was 86.0%,while for the control group,the total effective rate was 69.0%,the two groups were statistically different(P<0.05).After the treatment,patients’ scores of MMSE in the treatment group increased(P<0.05)and ADL decreased(P<0.05)significantly.Compared with the control group,the two groups had remarkable differences(P<0.05).Conclusion For the patients with mild to moderate vascular dementia,the combined use of butylphthalide soft capsules and donepezil can greatly improve the patients’ mental retardation and living skills,moreover it’s safe.