糖尿病患者血浆β血小板球蛋白和血小板第4因子的表达及意义

Expression and Clinical Significance of Plasma β Thromboglobulin and Platelet Factor 4 in Patients with Type 2 Diabetic Mellitus

目的:探讨血浆β血小板球蛋白(β-TG)和血小板第4因子(PF4)在糖尿病血管并发症形成过程中的作用。方法:ELISA法测定36例2型糖尿病并发血管性疾病患者β-TG和PF4含量,并与48例无血管性病变的2型糖尿病组和42例健康对照组比较。结果:2型糖尿病并发血管性疾病组血浆β-TG和PF4含量显著高于无血管病变组和健康对照组(P<0.01)。其水平高低与糖化血红蛋白(GHb)呈正相关(r=0.687和0.664,P<0.01),与甘油三酯(TG)水平无相关性(r=0.275和0.197,P>0.05)。结论:2型糖尿病患者β-TG和PF4的释放促进了血管病变的发生和发展。

Objective To investigate the role of plasma β thromboglobulin(β-TG)and platelet factor 4(PF4)in the progression of vascular complication in patients with type 2 diabetic mellitus.Methods The contents of β-TG and PF4 in 36 cases of type 2 diabetic mellitus complicated vascular disease were determined by ELISA,and then they were compared with 48 cases of type 2 diabetic mellitus without vascular disease and 42 cases of healthy control.Results The contents of β-TG and PF4 in type 2 diabetic mellitus complicate...