Effects of glycyrrhetinic acid on collagen metabolism of hepatic stellate cells at different stages of liver fibrosis in rats
被引量：29
Effects of glycyrrhetinic acid on collagen metabolism of hepatic stellate cells at different stages of liver fibrosis in rats
摘要
INTRODUCTIONLiver fibrosis is a dynamic course leading tocirrhosis from a various chronic liver diseases. Thepathological basis of fibrosis is the disturbance ofproduction and degradation of the extracellularmatrix (ECM), which causes accumulation of ECMin the liver[1,2].
基金
Project supported by the National Natural Science Foundation of China, No. 39500138
参考文献8
-
1王吉耀,郭津生,刘淑玲,MarkA.Zern.甘草甜素对肝硬化动物模型肝脏内NF一kB结合活性的抑制作用[J].中华肝脏病杂志,1999,7(1):42-43. 被引量：45
-
2郭津生,王吉耀,刘维田,余竹元.强力宁对四氯化碳、乙醇诱导的肝纤维化大鼠模型肝脏Ⅰ、Ⅲ型前胶原mRNA表达的影响[J].胃肠病学和肝病学杂志,1998,7(2):173-177. 被引量：29
-
3梁萍,薄爱华,薛贵平,韩瑞,李海峰,许永利.苦参碱抗免疫性肝损伤机制的研究[J].世界华人消化杂志,1999,7(2):104-108. 被引量：57
-
4严家春,马勇,陈文笔,孙新华.乙型肝炎肝纤维化及肝硬变的动态观察[J].华人消化杂志,1998,6(8):699-702. 被引量：29
-
5杨有权,王学国,李佳宁.国外昆虫性激素开发利用的现状[J].世界农业,1996(12):26-26. 被引量：1
-
6马捷,翟为溶,张月娥,周筱梅,杜卫东.Ⅲ型胶原在人和大鼠肝纤维化中的意义[J].上海医科大学学报,1995,22(4):244-249. 被引量：2
-
7孙丹莉,孙士其,李庭赞,陆雪龙.肝硬变时细胞外基质代谢的血清学研究[J].世界华人消化杂志,1999,7(1):55-56. 被引量：23
-
8王宝恩,王泰玲,贾继东,马红,段钟平,李新民,李佳,王爱民,钱林学.Experimental and Clinical Study on Inhibition and Reversion of Liver Fibrosis with Integrated Chinese and Western Medicine[J].Chinese Journal of Integrative Medicine,1999,5(1):6-11. 被引量：3
二级参考文献17
-
1高春芳.肝贮脂细胞与肝纤维化[J].临床肝胆病杂志,1994,10(3):125-128. 被引量：11
-
2朱家璇,王宝恩,王泰玲.冬虫夏草对实验性免疫损伤性肝纤维化的预防和治疗作用的研究[J].中华消化杂志,1994,14(6):333-335. 被引量：107
-
3李伟道,欧晓娟,叶红军,田玉静,刘世煊,张培林,刘晋萍,唐路红.血清Ⅲ型前胶原测定诊断肝纤维化的临床评价─—1199例分析[J].中华消化杂志,1995,15(4):237-238. 被引量：11
-
4钱绍诚.肝纤维化（肝硬化）的可逆性[J].中华消化杂志,1995,15(5):251-252. 被引量：134
-
5于世瀛,贲长恩,杨美娟,白锦雯,赵丽云.免疫性和化学性损伤肝纤维化动物模型的比较[J].实验动物科学与管理,1995,12(4):5-12. 被引量：60
-
6陈伟忠,张俊平,许青,胡振林,谢渭芬,张兴荣,马述春,胡和平,张贤康.苦参碱对大鼠实验性肝纤维化的影响[J].第二军医大学学报,1996,17(5):424-426. 被引量：116
-
7石淑仙.肝纤维化诊断与治疗的研究进展[J].实用医学进修杂志,1996,24(2):125-128. 被引量：3
-
8贾继东,王宝恩,董忠,崔林,朱家璇,车建途.中药861合剂对免疫损伤性肝纤维化大鼠肝脏Ⅰ、Ⅲ、Ⅳ型胶原及TGF－βmRNA的影响[J].中华肝脏病杂志,1996,4(4):214-216. 被引量：29
-
9贾继东,王宝恩,马雪梅.中药861合剂对体外培养贮脂细胞Ⅳ型胶原mRNA的影响[J].中华肝脏病杂志,1996,4(3):142-144. 被引量：15
-
10王宝恩,赵洪涛,王泰玲,刘遵昌,贾继东,任万华.复方861对肝炎肝纤维化疗效的病理组织学分析[J].中华肝脏病杂志,1997,5(2):77-78. 被引量：58
共引文献172
-
1赵宇亮,黎艳华,葛凤兰.苦参碱联合大剂量丹参注射液治疗病毒性肝炎高胆红素血症临床观察[J].中国实用医药,2006,1(5):25-26. 被引量：1
-
2陈文笔,严家春,马勇,徐长江.慢性乙型肝炎肝窦壁Ⅳ—型胶原的变化[J].南京部队医药,2002,4(2):5-8.
-
3Xin Huang1,Ding Guo Li1,Zhi Rong Wang1,Hong Shan Wei1,Ji Lin Cheng1,Yu Tao Zhan1,Xin Zhou1,Qin Fang Xu1,Xin Li2,Han Ming Lu1 1Xinhua Hospital, Shanghai Second Medical University, Shanghai 200092, China2Ninth Hospital. Shanghai Second Medical University, Shanghai 200011. China.Expression changes of activin A in the development of hepatic fibrosis[J].World Journal of Gastroenterology,2001,7(1):37-41. 被引量：12
-
4Hong-Chi Jiang~1 Bei Sun~1 Hai-Quan Qiao~1 Jun Xu~1 Da-Xun Piao~1 Hang Yin~2 1 Department of General Surgery,First Clinical Hospital,Harbin Medical University,Harbin 150001,China2 Department of General Surgery,Heilongjiang Provincial Hospital,Harbin 150001,China.Clinical application of serial operations with preserving spleen[J].World Journal of Gastroenterology,2001,7(6):876-879. 被引量：8
-
5Xiao-Xia Geng, Qin Yang, Ru-Jia Xie, Xin-Hua Luo, Cheng-Xiu Li and Ming-Liang Cheng Guizhou, China Department of Infectious Diseases, Affiliated Hospital of Guiyang Medical College ,Department of Pathophysiology, Guiyang Medical College ,Depart- ment of Infectious Diseases, People’ s Hospital of Guizhou Province ,and Department of Pharmacology, Guiyang Medical College.Effects of Dan-Shao-Hua-Xian on the expression of collagen type I and III in rats with hepatic fibrosis[J].Hepatobiliary & Pancreatic Diseases International,2004,3(4):558-563. 被引量：4
-
6郑伟强,庞超,龙尧.甘利欣胶囊治疗儿童慢性乙型肝炎肝纤维化的疗效观察[J].广东医学院学报,2004,22(3):251-252. 被引量：8
-
7李素婷.中药抗肝纤维化分子机制的研究概况[J].承德医学院学报,2004,21(3):257-259.
-
8李俊强,张孟孝,魏敏惠.分子生物学技术在中药开发中的应用[J].陕西中医学院学报,2004,27(5):50-51. 被引量：6
-
9周焕,黎彩霞.中西医结合治疗慢性乙型肝炎重度37例[J].中西医结合肝病杂志,2004,14(5):292-293.
-
10焦建中,葛勤利,弥建平.苦参碱治疗慢性肝病之研究进展[J].中西医结合肝病杂志,2004,14(4):254-256. 被引量：18
同被引文献260
-
1周正,张赤志,陈婕,周萍.抗纤软肝冲剂药物血清对肝星状细胞增殖的影响[J].中药材,2001,24(11):809-811. 被引量：2
-
2甘新宇,明德.PDGF与HSC中信号传导关系的研究进展[J].西南国防医药,2000,10(4):246-250. 被引量：1
-
3张光华,张凌云,张帆.软肝颗粒对CCl4致大鼠慢性肝损伤细胞因子TGFβ1,IL-1,TNF的影响[J].世界华人消化杂志,2000,8(z1). 被引量：2
-
4何庆玲,谢朝良,甘德春,古树林,米绍平,陈扬.转化生长因子β与透明质酸在人肝纤维化中的相关性研究[J].世界华人消化杂志,2000,8(z1). 被引量：2
-
5蔡卫民,翁红雷.γ-干扰素抗肝纤维化动物实验和临床疗效研究[J].世界华人消化杂志,2000,8(z1). 被引量：3
-
6李晓清,胡宝春,曾明新,凌奇荷.γ-干扰素对四氯化碳诱导的大鼠损伤肝细胞DNA和胶原合成及Ⅳ型胶原a3链mRNA的影响[J].世界华人消化杂志,2000,8(z1). 被引量：2
-
7Wen Jie Dai,Hong Chi Jiang Second Department of General Surgery, the First Clinical School, Harbin Medical University, Harbin 150001, Heilongjiang Province, China.Advances in gene therapy of liver cirrhosis: a review[J].World Journal of Gastroenterology,2001,7(1):1-8. 被引量：34
-
8Yu Cheng Tang,Yu Li,Guan Xiang Qian Department of Biochemistry, Shanghai Second Medical University, Shanghai 200025, China.Reduction of tumorigenicity of SMMC-7721 hepatoma cells by vascular endothelial growth factor antisense gene therapy[J].World Journal of Gastroenterology,2001,7(1):22-27. 被引量：33
-
9De Yun Feng,Hui Zheng,Yi Tan,Rui Xue Cheng Department of Pathology, Hunan Medical University, Changsha 410078, Hunan Province, China New England Biolab, MA, USA.Effect of phosphorylation of MAPK and Stat3 and expression of c-fos and c-jun proteins on hepatocarcinogenesis and their clinical significance[J].World Journal of Gastroenterology,2001,7(1):33-36. 被引量：76
-
10Hong Lei Weng,Wei Min Cai,Rong Hua Liu Institute of Infectious Diseases, First Affiliated Hospital. Medical School. Zhejiang University, Hangzhou 310003, Zhejiang Province. China.Animal experiment and clinical study of effect of gamma-interferon on hepatic fibrosis[J].World Journal of Gastroenterology,2001,7(1):42-48. 被引量：53
引证文献29
-
1Hong-Chi Jiang~1 Bei Sun~1 Hai-Quan Qiao~1 Jun Xu~1 Da-Xun Piao~1 Hang Yin~2 1 Department of General Surgery,First Clinical Hospital,Harbin Medical University,Harbin 150001,China2 Department of General Surgery,Heilongjiang Provincial Hospital,Harbin 150001,China.Clinical application of serial operations with preserving spleen[J].World Journal of Gastroenterology,2001,7(6):876-879. 被引量：8
-
2叶卉,陈志南,米力,商澎,骞爱荣,蒋建利,汪莉,谢丽,张敏.HAb18Gedomab1单抗的制备及功能研究[J].世界华人消化杂志,2004,12(9):2061-2065. 被引量：1
-
3周玉秀,刘恩令.自身免疫性肝炎患者血清抗中性粒细胞胞浆抗体的检测及其意义[J].临床荟萃,2005,20(4):203-204.
-
4韩红莉,杨柳絮,吴红样,赵中夫.HMGB1对肝星状细胞细胞外基质合成的影响[J].长治医学院学报,2009,23(2):85-87. 被引量：4
-
5杨晴,颜迎春,高彦欣.去纤软肝胶囊抗肝纤维化的实验与临床研究[J].世界华人消化杂志,2001,9(11):1246-1249. 被引量：12
-
6周馨,李宣海,李定国.库普弗细胞与肝纤维化[J].世界华人消化杂志,2002,10(1):65-68. 被引量：12
-
7ZhanXL,LiuL,等.Salvia miltiorrhiza monomer IH764-3 induces hepatic stellate cell apoptosis via caspase-3 activation[J].World Journal of Gastroenterology,2002,8(3):515-519. 被引量：25
-
8曹勤,蔡瑜,郭晓玲,朱新宇,董玲,沈锡中.甘草酸对四氯化碳诱导大鼠肝纤维化肝组织p53蛋白表达的影响[J].中华消化病与影像杂志（电子版）,2014,4(6):10-13. 被引量：1
-
9Ji-Cheng Li Shi-Ping Ding,Department of Lymphology,Department of Histology and Embryology, Medical College of Zhejiang University,Hangzhou 310031,Zhejiang Province,China Jian Xu,Hangzhou First People’ s Hospital,Hangzhou 310006,Zhejiang Province,China.Regulating effect of Chinese herbal medicine on the peritoneal lymphatic stomata in enhancing ascites absorption of experimental hepatofibrotic mice[J].World Journal of Gastroenterology,2002,8(2):333-337. 被引量：10
-
10Xiao-Jing Liu Ou Qiang Ming-Hui Huang Laboratory of Department of Internal Medicine,West China Hospital,Sichuan University,Chengdu 610041,Sichuan Province,China Li Yang Yi-Ping Wang Department of Gastroenterology of West China Hospital,Sichuan University,Chengdu 610041,Sichuan Province,China Hong-Bin Wu Laboratory of Department of Surgery,West China Hospital,Sichuan University,Chengdu 610041,Sichuan Province,China.Apoptosis of rat hepatic stellate cells induced by anti-focal adhesion kinase antibody[J].World Journal of Gastroenterology,2002,8(4):734-738. 被引量：17
二级引证文献277
-
1张玉蓉,朱晓宁,张秀,李晓媛,蒲清荣,汪静.和枢消积丸对二甲基亚硝胺诱导的小鼠肝损伤的保护作用研究[J].四川中医,2023,41(2):63-66. 被引量：2
-
2曾维政,吴晓玲,蒋明德,陈晓斌,李明秀,熊碧君,徐辉.复方红景天抗肝纤维化作用的实验研究[J].中国中西医结合杂志,2003,23(S1):96-99. 被引量：2
-
3司马辉,付雍,张海斌,朱楠,赵文超,杨宁,杨广顺.生长抑素对猪小体积肝移植术后门静脉压力梯度及供肝功能的影响[J].中华临床医师杂志（电子版）,2011,5(14):4141-4147.
-
4向其德,郑芳,姜浩,曹建国.5,4'-二-正辛烷氧基-7-二氟亚甲基异黄酮体外抗人类乳腺癌细胞作用[J].肿瘤研究与临床,2008,20(1):16-19.
-
5谈博,张奉学,刘妮,郭兴伯.丹参含药血清对肝星状细胞增生的抑制作用[J].世界华人消化杂志,2004,12(6):1357-1360. 被引量：5
-
6孟燕妮,张桂英,李乾.氯沙坦对肝纤维化鼠TIMP-1,PAI-1表达的影响[J].世界华人消化杂志,2004,12(6):1361-1364. 被引量：5
-
7柳丽,张洪泉.丹参活性成分的现代中药药理研究进展[J].中国野生植物资源,2003,22(6):1-4. 被引量：85
-
8王文兵,戴立里,郑元义.三七总皂甙对大鼠肝纤维化防治机制[J].世界华人消化杂志,2004,12(8):1939-1942. 被引量：7
-
9谢汝佳,杨勤,罗新华,耿晓霞,韩冰,李诚秀,程明亮.丹芍化纤胶囊对基质金属蛋白酶-1表达的影响[J].贵阳医学院学报,2004,29(5):395-399. 被引量：4
-
10叶卉,陈志南,米力,商澎,骞爱荣,蒋建利,汪莉,谢丽,张敏.HAb18Gedomab1单抗的制备及功能研究[J].世界华人消化杂志,2004,12(9):2061-2065. 被引量：1
-
1陈伟,马磊,杨立山.甘草次酸对支气管哮喘大鼠IgE、IL-4及TNF-α的影响[J].中药药理与临床,2015,31(3):52-55. 被引量：15
-
2戴令娟,双惊雷.川芎嗪治疗肺纤维化机制的探讨[J].医师进修杂志,1999,22(11):24-25. 被引量：22
-
3唐伟,刘煜,刘超.白介素-10与自身免疫性疾病[J].国外医学（内科学分册）,2004,31(5):206-209. 被引量：5
-
4刘克强,刘绛光,邹操.原发性高血压患者血清I型和Ⅲ型前胶原水平与左心室舒张功能关系的研究[J].中国心血管杂志,2001,6(3):151-154.
-
5赵建锋,杜杰,周淼,敖宇,代静静,兑丹华.重症急性胰腺炎肠屏障功能损伤机制研究进展[J].中国现代医药杂志,2016,18(4):91-94. 被引量：14
-
6梁茜,杨希立,林爱珍.The Contrast Study on Serum Collagen Metabolism between Essential Hypertension and Normal Control[J].South China Journal of Cardiology,2003,4(2):87-89.
-
7Zhi-Na Dun, Xiao-Lan Zhang, Jun-Yan An, Li-Bo Zheng, Robert Barrett, Shu-Rui Xie.Specific shRNA targeting of FAK influenced collagen metabolism in rat hepatic stellate cells[J].World Journal of Gastroenterology,2010,16(32):4100-4106. 被引量：8
-
8丛萌,平洁,敖英,汪晖.抗肝纤维化药物的研究进展[J].医学新知,2011,21(4):294-298. 被引量：1
-
9洪微,陈敏亮,孔宪涛,廖万清.Effect of integrin on procollagen synthesis by fibroblasts from scleroderma[J].Chinese Medical Journal,1999(11):65-68.
-
10王浦,陈烨,姜泊.艰难梭菌感染的流行病学研究进展[J].国际消化病杂志,2011,31(4):235-238. 被引量：3
