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Transretinoic acid inhibits rats gastric epithelial dysplasia induced by N-methyi-N-nitro-N-nitrosoguanidine:influences on cell apoptosis and expression of its regulatory genes 被引量:8

Transretinoic acid inhibits rats gastric epithelial dysplasia induced by N-methyi-N-nitro-N-nitrosoguanidine:influences on cell apoptosis and expression of its regulatory genes
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摘要 INTRODUCTIONGastric epithelial dysplasia (GED) hypothetically is a straight-forward concept: dysplastic epithelium replacing the normal gastric epithelium of the stomach [1].In the stomach ,like any other segment of the gut ,it is defined as an unequivocal non-invasive epithelial change[2,3].The observation of gastric dysplasia as a cancerous lesion was recognized over a century ago ,but it is only after the advent of gastroscopy that its clinical significance has been stressed[4-7].
出处 《World Journal of Gastroenterology》 SCIE CAS CSCD 2001年第3期394-398,共5页 世界胃肠病学杂志(英文版)
基金 Supported by the Science Fund of Health Department,No.95A2141.and the Science Fund of Health Bureau of Shanghai.No.982019
关键词 Animals Antigens CD95 Antineoplastic Agents Apoptosis Caspase 1 Cyclin D1 Gastric Mucosa Gene Expression Immunohistochemistry Male Membrane Glycoproteins METHYLNITRONITROSOGUANIDINE RNA Messenger RATS Rats Wistar Research Support Non-U.S. Gov't Stomach Diseases TRETINOIN stomach/pathology tretinoin/pharmacology apoptosis/drug effects proto-oncogene protein c-bcl-2/biosynthesis membrane glycoprotein/biosynthesis proto-oncogene mRNA c-bcl-2/biosynthesis membrane glycoprotein mRNA/biosynthesis
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  • 7Nagayo T.Histological diagnosis of biopsied gastric mucosae with special reference to that of borderline lesion[].Gann Monogr.1971
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  • 9Jiang SY,Shyu RY,Chen HY,Lee MMS,Wu KL,Yeh MY.In vitro and in vivo growth inhibition of SC MI gastric cancer cells by retinoic acid[].Oncology.1996
  • 10Cohen JJ.Exponential growth in apoptosis[].Immunology Today.1995

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