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Studies on mechanism of Sialy Lewis-X antigen in liver metastases of human colorectal carcinoma 被引量：19

Studies on mechanism of Sialy Lewis-X antigen in liver metastases of human colorectal carcinoma
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摘要 INTRODUCTIONSialyl Lewis-X antigen ,correlated with carcinoma, is a group of carbohydrate antigen containing oligosaccharide expressed of embryonic tisue and glycoproteins on cell surface of embryonic tissue[1].The SLeX antigen located on cell surface is synthesized principally by two enzymes ,al ,3fucosyltransfrease and a2, 3sialyctransferase.In adults ,SLeX antigen is expressed principally on the surfaces of granulocytic cells and some tumor cells .
作者 Xiao Wei Li~1 Yan Qing Ding~1 Jun Jie Cai~1 Shao Qing Yang~2 Lian Bing An~3 Dong Fang Qiao~3 ~1Department of Pathology,Nanfang Hospital of the First Military Medical University,Guangzhou 510515,Guangdong Province,China ~2The Northern Hospital of PLA,Shenyang 110015,Liaoning Province,China ~3Department of Electronmicroscopy,First Military Medical University,Guangzhou 510515,Gangdong Province,ChinaDr.Xiao Wei Li graduated from the First Military Medical University with a MM degree in 1999.Physician in Charge of pathology,having 6 papers published.
出处 《World Journal of Gastroenterology》 SCIE CAS CSCD 2001年第3期425-430,共6页 世界胃肠病学杂志（英文版）
基金 Supported by the Key Proqrams of PLA,No.96Z028
关键词 Animals Antibodies Monoclonal Antigens CD15 Cell Adhesion Colorectal Neoplasms E-Selectin Endothelium Vascular Flow Cytometry HT29 Cells Humans Immunohistochemistry In Situ Hybridization Liver Neoplasms MICE Mice Inbred BALB C Mice Nude Microscopy Electron Microscopy Electron Scanning N-Acetylneuraminic Acid RNA Messenger Research Support Non-U.S. Gov't Tumor Cells Cultured Umbilical Veins antigen, CD15s colorectal neoplasms/pathology liver neoplasms/secondary neoplasms metastasis tumor cells, cultured E-Selectin
分类号 R735.3 [医药卫生—肿瘤]
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参考文献13

  • 1BS Mitchell,H-P Horny,U Schumacher.Immunophenotyping of human HT29 colon cancer cell primary tumours and their metastases in severe combined immunodeficient mice[J].Journal of Molecular Histology.1997(5)
  • 2Dr. Shoji Nakamori M.D.,Masao Kameyama M.D.,Shingi Imaoka M.D.,Hiroshi Furukawa M.D.,Osamu Ishikawa M.D.,Yo Sasaki M.D.,Yuki Izumi M.S.,Tatsuro Irimura Ph.D.Involvement of carbohydrate antigen sialyl Lewisx in colorectal cancer metastasis[J].Diseases of the Colon & Rectum.1997(4)
  • 3Avraham Raz,Rcuben Lotan.Endogenous galactoside-binding lectins: a new class of functional tumor cell surface molecules related to metastasis[J].Cancer and Metastasis Review.1987(3)
  • 4Phillips ML,Nudelman E,Gaeta FCA,Perez M.Singhal AK,Hakomori SI,Paulson JC.ELAM-1 mediates tell adhesion by recognition of a carbohydrate ligand,sialyl-Le~x[].Science.1990
  • 5Singhal AK,Qrntoft TF.Nudelman E,Nance S,Schibig L,Stroud MR,Clausen H,Hakomori S.Profiles of lewis~x-containing glycoproteins and glycolipids in tara of patients with adenocarcinoma[].Cancer Research.1990
  • 6Hanski C,Drechsler K,Hanisch FG.Sheehan J,Manske M.Ogorek D,Klussmann E,Hanski ML,Blank M,Xing PX,McKenzie IFC,Devine PL,Riecken EO.Altered glycosylation of the MUC-1 protein core contributes to the colon carcinoma-associated increase of mucin-bound sialyl-lewis_x expression[].Cancer Research.1993
  • 7Liu HM,Gao TM,Tong ZQ.Expression of p53 mRNA and its protein in hippocampal CA1 region after reperfusion following global ischemia in rats[].Chinese Medical Journal.1999
  • 8Atkinson BF,Ernst CS,Herlyn M,Steplewski Z,Sears HF,Koprowski H.Gastrointestinal cancer-associated antigen in immunoperoxidase assay[].Cancer Research.1982
  • 9Berg EL,Robinson MK,Mansson O,Butcher EC,Magnani JL.A carbohydrate domain common to both sialyl Le~a and sialyl Le~x is recognized by the endothelial cell leukocyte adhesion molecule ELAM-1[].Journal of Biological Chemistry.1991
  • 10Sell S.Cancer-associated carbohydrates identified by monoclonal antibodies[].Human Pathology.1990

同被引文献144

引证文献19

二级引证文献191

World Journal of Gastroenterology
2001年 第3期

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