糖苷合成研究(ⅩⅦ)——1-芳磺酰基-3-N-(β-D-乙酰基葡萄糖醛酸甲酯-1-基)-5-氟脲嘧啶的合成和表征

STUDIES ON SYNTHESIS OF GLYCOSIDES(ⅩⅦ) -The Synthesis and Characterization of 1- Arylsulfonyl-3-n-(β-d-Methyl Acetylglucuronate-1-YL)-5-Fluorouracil

在相转移催化条件下 ,使 2 ,3,4 三 O 乙酰基 1 溴 1 脱氧 α D 葡萄糖醛酸甲酯与 1 芳磺酰基 5 氟脲嘧啶反应 ,合成了 5个新的 1 芳磺酰基 3 N ( β D 乙酰基葡萄糖醛酸甲酯 1 基 ) 5 氟脲嘧啶类化合物 ,其结构经IR、1HNMR及元素分析所证实 .

Five glucuronides of 1-arylsulfonyl-5-fluorouracil were synthesized by the reaction of 1-arylsulfonyl-5-fluorouracil 2 with methyl 2,3,4-tri-O-acetyl-1-bromo-1-deoxy-D-glucopyranuronate 1 under phase transfer catalysis.Their structures were confirmed by IR, 1HNMR and elementary analysis.