P^(53)蛋白表达与乳腺癌预后相关的病理参数的相关性

The Correlation between Expression of P^(53) protein and prognostic indicator in breast carcinoma

目的 观察P^(53)蛋白在乳腺癌中的表达及预后相关的病理参数之间的关系。方法 采用免疫组化法检测69例乳腺癌P^(53)、ER、PR的表达。结果 69例乳腺癌P^(53)蛋白表达阳性率47.8％、ER 75.4％、PR 69.6％。P^(53)蛋白表达与肿瘤组织学分级有密切关系(P<0.01),而与肿瘤的大小、腋下淋巴结浸润情况、雌孕激素受体没有关系(P>0.05)。结论 P^(53)蛋白表达与乳腺癌差的预后有关,对估计乳腺癌的预后可能具有临床意义。

Aim:Expression of P53 protein and prognostic indicator in brest carcinoma.Method:69 cases of breast carcinoma were studied for the expression P53 protein and Estrogen receptor and Progexterone receptor by means of immunohistochemistry. Results: The expression of P53 protein and ER,PR were 47.8% ,75.4% and 69.6% in breast carcinoma.It was found that there was a close reation ship between the expression of P53 protein and histologieal grade of tumor (P<0.01).It was found that tumor size, lymph nodes affected and hormone receptors didn' t correlate with theexpres-sion of P53 protein ( P > 0.05 ) . Conclusion: A close relationship was found between P53 protein expression and poorer prognosis factors in breast carci -noma It probably has clinical significance that P53 proteinexpression estimmates prognosis of breast carcinoma