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Bcl-2基因及家族成员与创伤性脑损伤 被引量：1

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摘要 Bcl-2基因及其家族成员可分为凋亡抑制基因和凋亡促使基因两类,在细胞凋亡中起着非常重要的作用,它们之间相互作用,共同构成一个非常复杂的网络,通过影响细胞线粒体的功能调控细胞凋亡,与创伤性脑外伤关系密切.
作者 尹卫东 许百男
机构地区 [
出处 《河南外科学杂志》 2001年第3期290-291,共2页 Henan Journal of Surgery
关键词 家族成员 脑损伤 BCL-2 创伤性 BAX 基因
分类号 R6 [医药卫生—外科学]
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参考文献10

  • 1Clark RSB,Kochanek PM,Adelson PD,et al.Increases in Bcl-2 protein in cerebrospinal fluid and evidence for programmed cell death in infants and chidren following severe traumatic brain injury[].The Journal of Pediatrics.2000
  • 2Lithgow T,Vandriol R,Bertram JF,et al.The protein product of the oncogene Bcl-2 is a component of the nuclear envelope, the endoplasmic reticulum, and the outer mitochondrial membrane[].Cell Growth and Differentiation.1994
  • 3Clark RSB,Cken J,Watkons SC,et al.A poptosis-suppressor gene Bcl-2 expression after traumatic brain injury in rats[].J Neurosur.1997
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  • 6Gonzalez-Garcia M,Garcia I,Ding L,et al.Bcl-x is expressed in embryonic and postnatal neural tissues and functions to prevent neuronal cell dearth[].Proceedings of the National Academy of Sciences of the United States of America.1995
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同被引文献11

  • 1胥学伟,李小鹰.甘油三酯脂酶家族中的新成员——内皮源性脂酶[J].中国分子心脏病学杂志,2003,3(6):359-362. 被引量：1
  • 2Marshall LF.Epidemiology and cost of central nervous system injury[J].Clin Neurosurg,2000,46(1):105-112.
  • 3McCarty JH.Cell adhesion and signaling networks in brain neurovascular units[J].Curr Opin Hematol,2009,16(3):209-214.
  • 4Vance JE.Lipid imbalance in the neurological disorder,Niemann-Pick C disease[J].FEBS Letts,2006,580(23):5518-5524.
  • 5Paradis E,Clavel S,Julien P,et al.Lipoprotein lipase and endothelial lipase expression in mouse brain:regional distribution and selective induction following kainic acid-induced lesion and focal cerebral ischemia[J].Neurobiol Dis,2004,15(2):312-325.
  • 6Logan A,Frautschy SA,Gonzalez AM,et al.A time course for the focal elevation of synthesis of basic fibroblast growth factor and one of its high-affinity receptors (flg) following a localized cortical brain injury[J].J Neurosci,1992,12(10):3828-3837.
  • 7Mattson MP,Cutler RG,Jo DG.Alzheimer peptides perturb lipid-regulating enzymes[J].Nat Cell Biol,2005,7(11):1045-1047.
  • 8Adibhatla RM,Hatcher JF,Dempsey RJ.Lipids and lipidomics in brain injury and diseases[J].AAPS J,2006,8(2):314-321.
  • 9Adibhatla RM,Hatcher JF,Dempsey RJ.Role of lipids in brain injury and diseases[J].Future Lipidol,2007,2(4):403-422.
  • 10Eldadah BA,Faden AI.Caspase pathways,neuronal apoptosis,and CNS injury[J].J Neurotrauma,2000,17(10):811-829.

引证文献1

河南外科学杂志
2001年 第3期

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