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HIV疫苗研制概况 被引量:3

The Brief Condition about Development of HIV Vaccine
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摘要 据WHO估计,到2000年年底,正遭受HIV/AIDS摧残的成人和儿童人数已达到3610万,仅2000年即有530万人感染HIV,其中包括60万15岁以下儿童.从HIV/AIDS流行到2000年年底,已有2180万人死于该病,而且死亡人数还在继续增加,仅2000年死于该病的人数就有300万[1].预防HIV的感染及发展成为AIDS是一个全球性迫切的公共健康性课题,在寻求预防和治疗方法的同时,从长远考虑,安全、可行、有效的抗HIV的疫苗是减少并消除该病的重要措施之一[2,3,4].美国前总统克林顿1997年发表了演说,号召全世界生物学及相关领域的科学家合作,用十年时间研制出HIV疫苗,这将是廿一世纪生物学的第一个胜利[5].现将HIV疫苗研究进展情况综述如下.
出处 《旅行医学科学》 2001年第1期27-30,共4页
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参考文献10

  • 1Mulligan MJ,& Weber J.Human trials of HIV-1 vaccines[].AIDS.1999
  • 2Ruprecht RM et al.a time to re-evaluate AIDS vaccine strategies[].Journal of Human Virology.2000
  • 3Lamgan M,& Collin S.Paving the road to an HIV Vaccine Employing Tods of Policy to Overcome. Scientific, Economic, Social and Ethical Obstacles[]..1998
  • 4Johnson RP,& Kalams S. The AIDS Knowledge Base . 1998
  • 5Levine A et al.Initial studies on active immunization for HIV-infected subjects using a gp120-depleted HIV-1 immunogen: long term follow-up[].J AIDS and Human Retrovirology.1996
  • 6Keefer MC et al.Safety profile for Phase Ⅰ and Phase Ⅱ preventive HIV type Ⅰ envelope vaccination: Experience for the NIAID AIDS Vaccine Evaluation Group[].AIDS Research and Human Retroviruses.1997
  • 7Nitayaphan S et al.A phase Ⅰ/Ⅱ trial of HIV SF2 gp120/MF59 vaccine in seronegative thais. AFRIMS-RIHES Vaccine Evaluation Group[].Vaccine.2000
  • 8O‘Hagan DT et al.Microparticles in MF59, a potent adjuvant combination for a recombinant protein vaccine against HIV-1[].Vaccine.2000
  • 9Connor RI et al.Immunlolgical and virological analyses of persons infected by HIV-1 while perticipating in trials of recombinant gp120 subunit vaccine[].Journal of Virology.1998
  • 10.AIDS Vaccine Moves into Phease 3 Trials[].The Journal of The American Medical Association.1998

同被引文献15

  • 1李萍,严家新.DNA疫苗研究进展[J].国外医学(预防.诊断.治疗用生物制品分册),1995,18(3):100-104. 被引量:9
  • 2Notka F, Stahl-Hennig C, Dittmer U, et al. Accelerated clearance of SHIV in rhesus monkeys by vires-like particle vaccines is dependent on induction of neutralizing antibodies. Vaccine, 1999,18(3-4) :291-301.
  • 3Kang CY, Luo L, Wainberg MA, et al. Development of HIV/AIDS vaccine using chimeric gag-env virus-like particles. Biol Chem, 1999,380 (3):353-364.
  • 4Peters BS, Cheingsong PR, Callow D, et al. A pilot phase Ⅱ study of the safety and immunogenicity of HIV p17/p24: VLP(p24--VLP) in asymp-tomatic HIV seropositive subjects. J Infect, 1997,35(3) :231-235.
  • 5Tobery TW, Smith JF, Kuklin N,et al. Effect of vaccine delivery system on the induction of HPV16L1-specific humoral and cell-mediated mmune responses in immunized rhesus macaques. Vaecine, 2003, 21 (13-14):1539-1547.
  • 6Lindenburg CE,Stolte I, Langendam MW, et al. Long-term follow-up: no effect of therapeutic vaccination with HIV-1 p17/p24: Ty virus-like particles on HIV-1 disease progression. Vaccine, 2002, 20 (17-18): 2343-2347.
  • 7Smith D, Gow I, Colebunders R, et al. Therapeutic vaccination (p24-VIP) of patients with advanced HIV-1 infection in the pre-HAART era does not alter CD4 cell decline. HIV Med,2001,2(4) :272-275.
  • 8Sutjipto S,Pedersen N C, Miller C J,et al. Inactivated simian immunodeficieney vires vaccine failed to protect rhesus macaques from intravenous orgenital mucosal infection but delayed disease in intravenously exposed animals. J Virol, 1990,64(5): 2290-2297.
  • 9Hadden JW.T-cell adjuvants, Int J Immunopharmacol, 1994, 16(9):703-710.
  • 10Lok AS,McMahon BJ.Chronic hepatitis B[J].Hepatology,2001,34:1225-40.

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