菲并吲哚里西啶生物碱及其盐衍生物的生物活性研究

Bioactivity of phenanthroindolizidine alkaloids and their salt derivatives

分别采用菌丝生长速率法和盆栽法,测定了一系列菲并吲哚里西啶生物碱及其盐衍生物的杀菌及除草活性。结果表明:该类生物碱及其盐衍生物表现出了很好的杀菌活性,尤其是生物碱安托芬[(±)-antofine](2)和脱氧娃儿藤宁碱[(±)-deoxytylophorinine](3)在50μg/mL下,对番茄早疫Alternaria solani、花生褐斑Cercospora arachidicola、苹果轮纹Physalospora piricola和黄瓜枯萎Cladosporium cucumerium4种菌体的抑制率达70%～100%;但未表现出明显的除草活性。

Fungicidal and herbicidal activity of a series of phenanthroindolizidine alkaloid and its salt derivatives were determined by mycelial growth method and pot experiment. The results showed that the alkaloid and derivatives have good fungicidal activity, especially (±)-antofine (2) and (±)-deoxytylophorinine (3),which showed 70%-100% inhibition rate against Alternaria solani,Cercospora arachidicola,Physalospora piricola and Cladosporium cucumerium at 50 μg/mL;however,the alkaloid and derivatives showed no her...